Non-apoptotic roles for death-related molecules: When mitochondria chose cell fate

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• 作者：Flavie Strappazzon^a ; ^b ; Silvia Campello^a ; ^c ; Francesco Cecconi^a ; ^b ; ^{francesco.cecconi@uniroma2.it}
• 关键词：Apoptosome ; Autophagy ; Caspases ; Mitochondrial dynamics
• 刊名：Experimental Cell Research
• 出版年：2012
• 期刊代码：292_00144827
• 类别：med
• 出版时间：1 July, 2012
• 卷：318
• 期：11
• 页码：1309-1315
• 文件大小：476 K

摘要

The decision between death and survival is a difficult phase of a cell life. It may depend on the intensity of a stress stimulus, on the presence of invasive pathogens, or on specific signals from neighbouring cells. Death-related molecules are being shown to possess different, and sometimes opposite roles, which they play also according to a number of environmental clues. In this review, we will analyse some of these molecules and their roles, with particular regard to mitochondria-related factors, such as BCL2 family members, the apoptosome components, the autophagy/death cross-talkers and molecules regulating mitochondrial structure and functions. Turning the double-edged swords of death molecules into plougshares may turn out to be strategically crucial in molecular oncology.