Meilleur pronostic des sujets de 45 ans et moins, atteints de cancer du poumon, li茅 au bon 茅tat g茅n茅ral et au stade TNM plus faible (茅tude r茅trospective et comparative)

详细信息	查看全文 | 推荐本文 |

• 作者：David Marquette¹ ; É ; ric Pichon¹ ; Guillaume Deschasse² ; ⁴ ; Bertrand Lemaire³ ; É ; tienne Lemarie¹ ; ⁵ ; Patrice Diot¹ ; ⁵ ; Sylvain Marchand-Adam¹ ; ⁵ ; ^{sylvain.marchand-adam@univ-tours.fr}
• 刊名：La Presse M¨|dicale
• 出版年：2012
• 期刊代码：pca289_07554982
• 类别：med
• 出版时间：June, 2012
• 卷：41
• 期：6_part_P1
• 页码：e250-e256
• 文件大小：228 K

摘要

| Figures/TablesFigures/Tables | ReferencesReferencesxml version="1.0" encoding="UTF-8"?>

Summary

Background

Bronchogenic carcinoma (BC) is a worldwide health public problem with a parallel but delayed development to smoking. The prognosis of BC in young patients is poorly known mainly because of few studies that have looked at this group of patients. The hypothesis of our study is that 鈥榶oung鈥?patients with BC have a better prognosis than others.

Methods

We conducted a retrospective epidemiologic study of all patients aged 45 and under (n = 73) followed for BC between 2002 and 2007 in two hospitals in the central region in France, compared with patients over 45 years random (n = 73). We evaluated the clinical characteristics (sex, smoking habits, WHO status, clinical presentation, histology, TNM stage), the management and prognosis of these patients.

Results

The median survival of patients aged 45 and under was 13.4&#xA0;months against 8.9&#xA0;months for patients over 45&#xA0;years. In multivariate analysis, age is not an independent prognostic factor (P&#xA0;=&#xA0;0.41) in contrast to the WHO status (P&#xA0;=&#xA0;0.002) and initial TNM stage (P&#xA0;<&#xA0;0.001). There was no significant difference for other clinical characteristics between the two patient populations.

Conclusion

In our study, the better prognosis of the 鈥測oung鈥?patient group is not directly related to age but in good condition and lower TNM stage of these patients.