In vitro growth inhibition of human cancer cells by novel honokiol analogs

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• 作者：Jyh Ming Lin^a ; ^&dagger ; ; ^{jml47@psu.edu} ; A.S. Prakasha Gowda^a ; ^&dagger ; ; Arun K. Sharma^b ; Shantu Amin^b
• 关键词：Honokiol analogs ; Cell proliferation ; CDK1 ; Cyclin B1 ; Human cancer cell
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2012
• 期刊代码：9_09680896
• 类别：ch
• 出版时间：15 May, 2012
• 卷：20
• 期：10
• 页码：3202-3211
• 文件大小：725 K

摘要

Honokiol possesses many pharmacological activities including anti-cancer properties. Here in, we designed and synthesized honokiol analogs that block major honokiol metabolic pathway which may enhance their effectiveness. We studied their cytotoxicity in human cancer cells and evaluated possible mechanism of cell cycle arrest. Two analogs, namely 2 and 4, showed much higher growth inhibitory activity in A549 human lung cancer cells and significant increase of cell population in the G0-G1 phase. Further elucidation of the inhibition mechanism on cell cycle showed that analogs 2 and 4 inhibit both CDK1 and cyclin B1 protien levels in A549 cells.