Clinical Saccharomyces cerevisiae isolates cannot cross the epithelial barrier in vitro

详细信息	查看全文 | 推荐本文 |

• 作者：Roberto Pé ; rez-Torrado^a ; ^{rober@iata.csic.es} ; Silvia Llopis^a ; Lene Jespersen^b ; Teresa Ferná ; ndez-Espinar^a ; Amparo Querol^a
• 关键词：Yeast ; Saccharomyces cerevisiae ; Clinical ; Intestinal barrier
• 刊名：International Journal of Food Microbiology
• 出版年：2012
• 期刊代码：63_01681605
• 类别：abs
• 出版时间：15 June, 2012
• 卷：157
• 期：1
• 页码：59-64
• 文件大小：528 K

摘要

Saccharomyces cerevisiae is generally considered to be a safe organism and is essential to produce many different kinds of foods as well as being widely used as a dietary supplement. However, several isolates, which are genetically related to brewing and baking yeasts, have shown virulent traits, being able to produce human infections in immunodeficient patients. Previously it has been shown that the administration of S. cerevisiae clinical isolates can lead to systemic infections, reaching several organs in murine systems. In this work, we studied S. cerevisiae clinical isolates in an in vitro intestinal epithelial barrier model, comparing their behaviour with that of several strains of the related pathogens Candida glabrata and Candida albicans. The results showed that, in contrast to C. glabrata and C. albicans, S. cerevisiae was not able to cross the intestinal barrier. We concluded that S. cerevisiae can only perform opportunistic or passive crossings when epithelial barrier integrity is previously compromised.