Immature platelet fraction as marker for platelet recovery after stem cell transplantation in children

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• 作者：Eva Hennel^b ; ¹ ; Karim Kentouche^a ; ¹ ; James Beck^a ; Michael Kiehntopf^b ; Klas Boeer^b ; ^{klas.boeer@med.uni-jena.de}
• 关键词：Immature platelet fraction ; IPF ; Stem cell transplantation ; Thrombopoiesis
• 刊名：Clinical Biochemistry
• 出版年：2012
• 期刊代码：55_00099120
• 类别：med
• 出版时间：July, 2012
• 卷：45
• 期：10-11
• 页码：749-752
• 文件大小：330 K

摘要

Objectives

Thrombocytopenia occurs in pediatric patients after SCT and has to be treated with platelet transfusions which bear certain risks and represent a significant cost factor. Monitoring immature platelet (IPF) fraction has been proposed to predict platelet recovery thereby reducing the need for transfusions.

Design and methods

Hematological parameters including IPF were systematically studied in 17 pediatric patients after either peripheral blood or bone marrow stem cell transplantation.

Results

Time to platelet recovery depended on the source of stem cells while no differences were detected between percentaged IPF peak concentration and time between IPF peak concentration and platelet recovery between the groups. Correlation between the timepoints of percentaged IPF peak and platelet recovery was high but large interindividual differences were observed concerning the duration of this period. In addition, in some patients high IPF concentrations were not followed by platelet recovery.

Conclusions

Although in general high IPF concentrations are followed by platelet recovery wide interindividual variations exist and even no recovery was recorded in four patients. As the latter children are not readily identifiable beforehand IPF should not be used to omit platelet transfusions.