Potent and selective xanthine-based inhibitors of phosphodiesterase 5

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• 作者：Nichola J. Arnold ; Ruth Arnold ; David Beer ; Gurdip Bhalay ; Stephen P. Collingwood ; Sarah Craig ; Nicholas Devereux ; Mark Dodds ; Andrew R. Dunstan ; Robin A. Fairhurst ; et al.
• 关键词：Phosphodiesterase 5 ; Xanthine ; Erectile dysfunction
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2007
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：15 April 2007
• 卷：17
• 期：8
• 页码：2376-2379
• 文件大小：168 K

摘要

Inhibitors of PDE5 are useful therapeutic agents for treatment of erectile dysfunction. A series of novel xanthine derivatives has been identified as potent inhibitors of PDE5, with good levels of selectivity against other PDE isoforms, including PDE6. Studies in the dog indicate excellent oral bioavailability for compound 21.