Suppression of ovarian activity with a low-dose 21/7-day regimen oral contraceptive containing ethinylestradiol 20 mcg/drospirenone 3 mg in Japanese and Caucasian women

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• 作者：Yuzuru Anzai^a ; ^{yuzuru.anzai@nyumc.org} ; Doris Heger-Mahn^b ; Ilka Schellschmidt^c ; Joachim Marr^c
• 关键词：Low-estrogen dose COCs ; Ovulation inhibition ; Japanese and Caucasian women
• 刊名：Contraception
• 出版年：2012
• 期刊代码：71_00107824
• 类别：med
• 出版时间：July, 2012
• 卷：86
• 期：1
• 页码：28-34
• 文件大小：282 K

摘要

Background

Two studies assessed the effect of a low-estrogen-dose 21/7-day oral contraceptive containing ethinylestradiol and drospirenone (EE 20 mcg/drsp 3 mg) on ovarian activity in Japanese and Caucasian women.

Study Design

Study 1 was conducted in Japanese women (20-35 years), and Study 2 was conducted in Caucasian women (18-35 years). All women received EE 20 mcg/drsp 3 mg in a 21-day active pill regimen. The primary endpoint was the proportion of women with ovulation inhibition (Hoogland score <6; as assessed by transvaginal ultrasonography) during treatment cycle 2.

Results

Japanese (n=23) and Caucasian (n=30) women received two cycles of study treatment. During treatment cycle 2, ovulation was inhibited in 100%and 92.9%of Japanese and Caucasian women, respectively.

Conclusions

EE 20 mcg/drsp 3 mg in a 21/7-day regimen provides comparable ovarian suppression in Japanese and Caucasian women, with normal ovarian function resuming shortly after treatment end in both populations.