Studies of the mechanism of the in-loop synthesis of radiopharmaceuticals

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• 作者：Studenov ; Andrei R. ; Jivan ; Salma ; Adam ; Michael J. ; Ruth ; Thomas J. ; Buckley ; Kenneth R.
• 关键词：[¹¹C]Methyliodide ; [¹¹C]Carfentanil ; [¹¹C]SCH23390 ; [¹¹C]DTBZ ; In-loop radiosynthesis ; Positron emission tomography
• 刊名：Applied Radiation and Isotopes
• 出版年：2004
• 期刊代码：6_09698043
• 类别：ce
• 出版时间：December, 2004
• 卷：61
• 期：6
• 页码：1195-1201
• 文件大小：218 K

摘要

A series of experiments were performed to better understand the mechanism of the In-loop [¹¹C]CH₃I-methylation. The timing of [¹¹C]CH₃I delivery is critical for the high yield of radiolabeling since in-loop radioactivity trapping is reversible. Trapped radioactivity escapes faster from a Tefzel loop compared to a PEEK- or stainless steel loop. Up to 50%of delivered radioactivity may be concentrated at the loop origin (representing 8.1%of the total loop volume). A five-fold reduction of the reaction solvent volume and/or precursor amount may lead to a decrease of the product radiochemical yield either by lowering the in-loop radioactivity trapping or by diminishing conversion of [¹¹C]CH₃I into the product.