Quantification of brain μ-opioid receptors with [¹¹C]carfentanil: reference-tissue methods

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• 作者：Endres ; Christopher J. ; Bencherif ; Badreddine ; Hilton ; John ; Madar ; Igal ; James Frost ; J.
• 关键词：Mu-opioid receptors ; Opiates ; [¹¹C]carfentanil ; Positron emission tomography
• 刊名：Nuclear Medicine and Biology
• 出版年：2003
• 期刊代码：43_09698051
• 类别：ph
• 出版时间：February, 2003
• 卷：30
• 期：2
• 页码：177-186
• 文件大小：179 K

摘要

[¹¹C]Carfentanil (CFN) is a μ-opioid agonist used for in vivo positron emission tomography (PET) studies of μ-opioid receptors. Previously, a tissue-ratio method was validated for the quantification of CFN binding. However, since that initial validation, several other blood independent (reference-tissue) methods have become available. To evaluate these methods, CFN PET studies with arterial blood sampling were acquired in six healthy male control subjects. Specific binding estimates obtained from reference-tissue methods were compared to those obtained with a more rigorous blood input modeling technique. It was determined that both a graphical method, and a simplified reference tissue model, were more accurate than the tissue-ratio method for quantification of CFN binding.