A regulatory instead of an IL-17 T response predominates in Helicobacter pylori-associated gastritis in children

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• 作者：Fabr&iacute ; cio Freire de Melo^a ; ^b ; Andreia Maria Camargos Rocha^a ; Gifone Aguiar Rocha^a ; Silvia Helena Sousa Pietra Pedroso^a ; S&eacute ; rgio de Assis Batista^a ; ^b ; L&uacute ; cia Porto Fonseca de Castro^c ; Simone Diniz Carvalho^d ; Paulo Fernando Souto Bittencourt^d ; Celso Afonso de Oliveira^a ; Rodrigo Corrê ; a-Oliveira^e ; Dulciene Maria Magalh&atilde ; es Queiroz^a ; ^{dqueiroz@medicina.ufmg.br}
• 关键词：Helicobacter pylori ; Th17 ; Treg ; Children ; Adults
• 刊名：Microbes and Infection
• 出版年：2012
• 期刊代码：65_12864579
• 类别：imm
• 出版时间：April, 2012
• 卷：14
• 期：4
• 页码：341-347
• 文件大小：503 K

摘要

Th17 cells seem to have an important role in the efficacy of vaccines against Helicobacter pylori. Because children are a target group for human vaccination and Th17/T_reg cells have intrinsically linked and antagonic commitments, we compared the gastric levels of Th17- and T_reg-associated cytokines of children and adults. IL-6, IL-10 and TGF-尾1 levels and Foxp3⁺ cell numbers were higher, but IL-1尾, IL-17A and IL-23 were lower in infected children than in infected adults. In conclusion T_reg instead of Th17 cell response to H. pylori-infection predominates in children.