Early dysregulation of hippocampal proteins in transgenic rats with Alzheimer's disease-linked mutations in amyloid precursor protein and presenilin 1

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• 作者：Vercauteren ; Freya G.G. ; Clerens ; Stefan ; Roy ; Line ; Hamel ; Nathalie ; Arckens ; Lut ; Vandesande ; Frans ; et. al.
• 关键词：Disorders of the nervous system ; Degenerative diseases ; Alzheimer's脙脙脙脙脙脙miscellaneous ; Brain mapping ; Two-dimensional gel electrophoresis ; Nerve degeneration ; Hippocampus ; Amyloid precursor protein ; Presenilin 1 ; Alzheimer's disease ; Learning ; Memo
• 刊名：Molecular Brain Research
• 出版年：2004
• 期刊代码：40_0169328x
• 类别：neu
• 出版时间：December 20, 2004
• 卷：132
• 期：2
• 页码：241-259
• 文件大小：542 K

摘要

The response of the hippocampal proteome to expression of mutant proteins present in familial forms of Alzheimer's disease (AD) was studied using transgenic rats. These animals carry both the amyloid precursor protein Swedish and 717 mutation (APP_SW+717) as well as the presenilin 1 Finnish mutation (PS1_FINN). This transgenic rat model displays intracellular amyloid beta (A脦脦) in neurons of the neocortex and the hippocampus (CA2 and CA3). The hippocampus was selected as it is one of the first brain regions affected in AD and is involved in the processing of short-term memory and spatial memory.