Transforming growth factor β receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells

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• 作者：Chattopadhyay ; Naibedya ; T-Felt Hansen ; Jacob ; Godbole ; Madan M. ; Brown ; Edward M.
• 关键词：Disorders of the nervous system ; Neuro-oncology ; Activin-A ; BMP ; Tumor ; Proliferation ; Angiogenesis
• 刊名：Molecular Brain Research
• 出版年：2004
• 期刊代码：40_0169328x
• 类别：neu
• 出版时间：February 5, 2004
• 卷：121
• 期：1-2
• 页码：146-150
• 文件大小：447 K

摘要

Transforming growth factor β (TGFβ) and hepatocyte growth factor (HGF) promote glioma progression. Using U87human astrocytoma cells, which express TGFβ receptors (TβRs), we show (1) mRNA expression of Smads (2, 3, 4), bone morphogenetic protein (BMP)- and activin-A receptors; (2) TGFβ1 inhibits and HGF induces proliferation; (3) TGFβ1 and activin-A equipotently inhibit HGF secretion more than BMP-2, but none alters c-Met expression. Because interfering with TβR signaling might nullify the beneficial inhibition of HGF secretion, activin-A should instead be considered for combination glioma therapy.