Disruption of overshadowing and latent inhibition in high schizotypy individuals

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• 作者：K.T. Granger¹ ; J. Prados ; A.M.J. Young ; ^{amjy1@le.ac.uk}
• 关键词：CogDis ; cognitive disorganisation ; CS ; conditioned stimulus ; ImpNon ; impulsive nonconformity ; IntAn ; introvertive anhedonia ; LI ; latent inhibition ; NPE ; non-preexposed ; O-LIFE ; Oxford-Liverpool Inventory of Feelings and Experiences ; OS ; overshadowing ; PE
• 刊名：Behavioural Brain Research
• 出版年：2012
• 期刊代码：3_01664328
• 类别：neu
• 出版时间：15 July, 2012
• 卷：233
• 期：1
• 页码：201-208
• 文件大小：609 K

摘要

Deficits in selective attention are seen in positively symptomatic schizophrenia sufferers, and in normal people displaying schizotypal traits. We investigated the relationship between selective attention and schizotypy in undergraduate students, by comparing participants鈥?performance in two models of selective attention, overshadowing and latent inhibition, with psychoticism scores derived from the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE). Using a novel within-subject overshadowing task, we showed that the unusual experiences dimension of schizotypy, but not the other three O-LIFE dimensions, was negatively related to overshadowing score. We also replicated findings that the unusual experiences dimension of schizotypy was negatively related to latent inhibition score. These experiments provide evidence that selective attention is disrupted in normal individuals showing traits relating to positive-like schizophrenic symptoms, and has implications for interpreting selective attention deficits measured in schizophrenia patients.