FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumors: van Oers JM, Wild PJ, Burger M, Denzinger S, Stoehr R, Rosskopf E, Hofstaedter F, Steyerberg

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• 作者：H. Barton Grossman
• 关键词：Climate change ; Irrigation ; Farm revenues ; Ricardian model
• 刊名：Urologic Oncology ; Seminars and Original Investigations
• 出版年：2008
• 期刊代码：266_10781439
• 类别：med
• 出版时间：May-June 2008
• 卷：26
• 期：3
• 页码：331-332
• 文件大小：66 K

摘要

In a prospective study, immunocytochemistry for CK20 was done on tumours of all patients who presented for the first time with non-invasive papillary bladder tumours. We classified the expression pattern of CK20 as normal or abnormal at the time of initial diagnosis. We recorded time to first biopsy-proven recurrence or length of follow-up when no recurrence was observed.

Findings

Of 58 consecutive patients, ten had tumours with a normal pattern of CK20 expression. No patients developed further tumours during the follow-up (median 18 [range 13–28] months). By contrast, 30 (73%) of the 41 evaluable patients with tumours that showed abnormal CK20 expression developed further tumours; the median time to a second tumour was 6 (2–24) months. The only factor that had a significant effect on the outcome of patients in terms of recurrence was expression of CK20 (p<0·0001).

Interpretation

Normal urothelial differentiation, as evidenced by a normal pattern of CK20 expression, is retained in a proportion of non-invasive papillary urothelial tumours and thus justifies use of the term urothelial papilloma. A large-scale study is needed to investigate the outcome of patients with such tumours.