Application of palladium-catalyzed Pd–aryl/P–aryl exchanges: preparation of functionalized aryl phosphines by phosphination of aryl bromides using triarylphosphines
- 作者：Kwong ; Fuk Yee ; Lai ; Chi Wai ; Yu ; Michael ; Chan ; Kin Shing
- 关键词：Phosphination ; Palladium ; Triphenylphosphine ; Triarylphosphine ; Cross-coupling ; Catalysis
- 刊名：Tetrahedron
- 出版年：2004
- 期刊代码：107_00404020
- 类别：ch
- 出版时间：June 21, 2004
- 卷：60
- 期：26
- 页码：5635-5645
- 文件大小：609 K
摘要
Palladium-catalyzed Pd–aryl/P–aryl interchange reaction was applied in the synthesis of various functionalized arylphosphines. This phosphination used inexpensive, readily available and air stable triarylphosphines as the phosphinating agents. Broad functional groups were compatible including keto, aldehyde, ester, nitrile, ether, chloride, pyridyl and thiophenyl groups. Halides were found to be good promoter for the rates and yields of the reaction.