Effectiveness of MF59™-adjuvanted subunit influenza vaccine in preventing hospitalisations for cardiovascular disease, cerebrovascular disease and pneumonia in the elderly
- 作者：Joan Puig-Barberà ; Javier Dí ; ez-Domingo ; Á ; ngel Belenguer Varea ; Germá ; n Schwarz Chavarri ; José ; A. Lluch Rodrigo ; Santiago Pé ; rez Hoyos ; David Gonzá ; lez Vidal
- 关键词：MF59™ ; -adjuvanted subunit influenza vaccine ; Cardiovascular diseases ; Cerebrovascular disorders ; Pneumonia ; Elderly ; Influenza
- 刊名：Vaccine
- 出版年：2007
- 期刊代码：89_0264410x
- 类别：imm
- 出版时间：16 October 2007
- 卷：25
- 期：42
- 页码：7313-7321
- 文件大小：337 K
摘要
Annual circulation of influenza virus coincides with a peak in cardiovascular and pneumonia mortality/morbidity. This study aimed to determine the effectiveness of MF59™-adjuvanted subunit influenza vaccine in preventing hospitalisation due to acute coronary syndrome (ACS), cerebrovascular accident (CVA) and pneumonia in the elderly. Three case–control studies were performed during the 2004–2005 influenza season in three health districts in Valencia, Spain (total elderly [>64 years of age] population: n = 105,454). Controls were patients admitted for an acute surgical process or trauma within 10 days of case admission. In total, 159 patients were hospitalised for ACS, 148 for CVA and 242 for pneumonia. The risk of hospitalisation after the start of the influenza season was significantly lower in vaccinated patients compared with non-vaccinated patients (adjusted odds ratios: 0.13 [P = 0.013] for ACS; 0.07 [P = 0.007] for CVA; 0.31 [P = 0.005] for pneumonia). During peak virus circulation, vaccination with MF59™-adjuvanted subunit influenza vaccine was associated with an 87%relative risk reduction in hospitalisation for ACS, 93%for CVA, and 69%for pneumonia.