Tigliane diterpene esters with IFN 纬-inducing activity from the leaves of Aleurites fordii

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• 作者：Yi-Hua Pei^a ; Jae Wha Kim^b ; Ho-Bum Kang^b ; Hyeong-Kyu Lee^a ; ^c ; Chan-Soo Kim^e ; Hyuk-Hwan Song^c ; Young-Won Chin^d ; Sei-Ryang Oh^a ; ^c ; ^{seiryang@kribb.re.kr}
• 关键词：Aleurites fordii ; Euphorbiaceae ; Tigliane diterpene ; Phorbol ; IFN-纬 production
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：15 March, 2012
• 卷：22
• 期：6
• 页码：2318-2320
• 文件大小：324 K

摘要

Bioactivity-guided fractionation on the leaves of Aleurites fordii led to the isolation of a new tigliane diterpene ester, 12-O-hexadecanoyl-7-oxo-5-ene-16-hydroxyphorbol-13-acetate (1) along with four known compounds, 12-O-hexadecanoyl-7-oxo-5-ene-phorbol-13-acetate (2), 12-O-hexadecanoyl-phorbol-13-acetate (3), 12-O-hexadecanoyl-16-hydroxyphorbol-13-acetate (4), and 12-O-hexadecanoyl-4-deoxy-4伪-16-hydroxyphorbol-13-acetate (5). The structures of these compounds were determined by interpretation of NMR (1D and 2D) spectroscopic data and MS data. All the isolates were evaluated for their effects on the induction of IFN-纬 in NK92 cells. Compounds 3 and 4 exhibited the most potent responses in IFN-纬 induction, comparable to the positive control, phorbol 12-myristate 13-acetate (PMA).