Gene expression in the Parkinson's disease brain

详细信息	查看全文 | 推荐本文 |

• 作者：Patrick A. Lewis^a ; ^{patrick.lewis@ucl.ac.uk} ; Mark R. Cookson^b ; ^{cookson@mail.nih.gov}
• 关键词：Parkinson's disease ; Microarray ; Gene expression ; Neuropathology ; Genome wide
• 刊名：Brain Research Bulletin
• 出版年：2012
• 期刊代码：9_03619230
• 类别：neu
• 出版时间：1 July, 2012
• 卷：88
• 期：4
• 页码：302-312
• 文件大小：488 K

摘要

The study of gene expression has undergone a transformation in the past decade as the benefits of the sequencing of the human genome have made themselves felt. Increasingly, genome wide approaches are being applied to the analysis of gene expression in human disease as a route to understanding the underlying pathogenic mechanisms. In this review, we will summarise current state of gene expression studies of the brain in Parkinson's disease, and examine how these techniques can be used to gain an insight into aetiology of this devastating disorder.