Detection of metastatic colon cancer cells in sentinel nodes by flow cytometry
- 作者：Mona Karlsson ; Olle Nilsson ; Magnus Thö ; rn ; Ola Winqvist
- 关键词：Sentinel node ; Flow cytometry ; Colon cancer ; Lymphatic metastases ; Tumour staging
- 刊名：Journal of Immunological Methods
- 出版年：2008
- 期刊代码：57_00221759
- 类别：imm
- 出版时间：20 May 2008
- 卷：334
- 期：1-2
- 页码：122-133
- 文件大小：1886 K
摘要
In colon cancer the presence of metastases in the regional lymph nodes is an important prognostic factor. Currently, examination is based on histological and immunohistochemical evaluations of lymph node sections. However, these methods are time-consuming, labour intensive and micro-metastases might be missed. The sentinel node technique may be used to identify the direct tumour draining lymph node. In this study the possible use of flow cytometry for detection of sentinel node metastases in patients with colon cancer has been investigated.