Inhibition of human 5-HT_3A and 5-HT_3AB receptors by etomidate, propofol and pentobarbital

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• 作者：Dirk Rü ; sch ; Hans A. Braun ; Hinnerk Wulf ; Anika Schuster ; Douglas E. Raines
• 关键词：Etomidate ; Propofol ; Pentobarbital ; 5-HT_3A receptor ; 5-HT_3AB receptor
• 刊名：European Journal of Pharmacology
• 出版年：2007
• 期刊代码：24_00142999
• 类别：neu
• 出版时间：14 November 2007
• 卷：573
• 期：1-3
• 页码：60-64
• 文件大小：201 K

摘要

The actions of intravenous anaesthetics on 5-HT_3AB receptors have not been studied. Using oocyte electrophysiology, the effects of etomidate, propofol, and pentobarbital on human 5-HT_3A and 5-HT_3AB receptors were studied and compared. Inhibition of peak currents by all three compounds in both receptor subtypes was anaesthetic concentration-dependant and non-competitive. Because the half-maximal inhibitory concentrations for etomidate, propofol and pentobarbital in 5-HT_3A and 5-HT_3AB receptors were all above their respective anaesthetic concentrations, the results of our study suggest that neither 5-HT₃ receptor subtype contributes to the anaesthetic actions of etomidate, propofol or pentobarbital.