Fractional anisotropy values detect pyramidal tract involvement in multiple system atrophy

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• 作者：Mizuki Ito ; Hirohisa Watanabe ; Naoki Atsuta ; Jo Senda ; Yoshinari Kawai ; Fumiaki Tanaka ; Shinji Naganawa ; Hiroshi Fukatsu ; Gen Sobue
• 关键词：Multiple system atrophy ; Pyramidal tract involvement ; Fractional anisotropy values ; Amyotrophic lateral sclerosis ; Small-sized neuron ; Tractography
• 刊名：Journal of the Neurological Sciences
• 出版年：2008
• 期刊代码：178_0022510x
• 类别：med
• 出版时间：15 August 2008
• 卷：271
• 期：1-2
• 页码：40-46
• 文件大小：581 K

摘要

Pathological studies have shown remarkable pyramidal tract involvement in multiple system atrophy (MSA), while clinical pyramidal signs are relatively rare. We investigated the fractional anisotropy (FA) values to assess the degree of pyramidal tract involvement in MSA, in comparison with amyotrophic lateral sclerosis (ALS) and controls. Furthermore, we compared FA values between MSA patients with or without clinical pyramidal signs and controls, and between MSA patients with or without positive conventional MRI findings and controls.