- 作者：Raquel Blanes Zamora ; rblaneszamora@yahoo.es ; Rebeca Vaca Sá ; nchez ; Jonay Gonzá ; lez Pé ; rez ; Delia Bá ; ez Quintana ; Rubí ; Rodrí ; guez Dí ; az ; José ; Carlos Alberto Bethencourt
- 关键词：Pentoxifilina ; TESE fresca ; TESE congelada ; Movilidad espermá ; tica
- 刊名：Revista Internacional de Androlog铆a
- 出版年：2008
- 期刊代码：pca322_1698031X
- 类别：med
- 出版时间：December 2008
- 卷：6
- 期：4
- 页码：242-248
- 文件大小：113 K
Objectives
Pentoxifylline (PTX) activates sperm motility. Our objective is to evaluate whether PTX improves ICSI with testicular biopsy (TESE) results given that it common to find.
Material and methods
We analysed 101 ICSI with TESE cycles, in which we we assessed female age, oocyte number, mature oocytes, fertilization rate, division rate, optimal embryos, transferred embryos, gestation rate by microinjection and by transfer. We compared, by infertility cause; fresh or frozen TESE; motile or immotile spermatozoa; vasectomized or azoospermic patients, and whether PTX was used or not.
Results
Less optimal embryos were obtained with mixed infertility causes (1.6 vs. 2.3; p < 0.05). Although fewer embryos were transferred with freez-thawed TESE (1.53 vs. 2.16) they still had the same pregnancy rate as fresh. Microinjection of immotile spermatozoa gave lower fertilization rates and lower pregnancy rates. There were no differences between vasectomized and azoospermic patients. The groups with and without PTX showed no significant differences.
Discussion
The same results were found with fresh and frozen TESE. PTX does activate sperm motility, and in all cases where motile sperm was microinjected motile sperm there was improved fertilization and pregnancy rates.