Prevention of recurrent bacterial urinary tract infections by intravesical instillation of hyaluronic acid

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• 作者：M. Lipovac ; C. Kurz ; F. Reithmayr ; H.C. Verhoeven ; J.C. Huber ; M. Imhof
• 关键词：Bladder instillation ; Cystitis ; Glycosaminoglycans ; Hyaluronic acid ; Urinary tract infection
• 刊名：International Journal of Gynecology and Obstetrics
• 出版年：2007
• 期刊代码：130_00207292
• 类别：med
• 出版时间：March 2007
• 卷：96
• 期：3
• 页码：192-195
• 文件大小：135 K

摘要

>Objective:

To evaluate the efficacy of vesical instillation of hyaluronic acid against recurrent urinary tract infections.

Methods:

Twenty women with a history of recurrent urinary tract infections each received 9 intravesical instillations of hyaluronic acid over 6 months. Their status was assessed prospectively over 47.6 weeks and compared with a retrospective review of patient charts covering 36.2 ± 6.2 weeks.

Results:

The total numbers of urinary tract infections were 67 before and 10 after treatment (p < 0.001). Thirteen patients (65%) were free of recurrences until the end of the study. One had a recurrence during treatment, and 6 (30%) during follow-up. The number of infections per year per patient was reduced from 4.99 ± 0.92 to 0.56 ± 0.82 (p < 0.001). In women with recurrences, time to recurrence was 178.3 ± 25.5 days, compared with 76.7 ± 24.6 days before treatment (p < 0.001).

Conclusion:

Intravesical instillation of hyaluronic acid is effective in preventing recurrent urinary tract infections.