• 作者：M. Benkiran ; ^{meriembenkiran@hotmail.fr} ; L. Sibille ; A. Bourdon ; F. Ben Bouallegue ; D. Mariano-Goulart
• 关键词：Scintigraphie myocardique de perfusion ; Artefacts d&rsquo ; atté ; nuation ; Correction d&rsquo ; atté ; nuation
• 刊名：Mé ; decine Nuclé ; aire
• 出版年：2012
• 期刊代码：219_09281258
• 类别：med
• 出版时间：May, 2012
• 卷：36
• 期：5
• 页码：243-256
• 文件大小：2869 K

Myocardial perfusion SPECT is a routine for the assessment of patients with coronary artery disease (CAD). However, attenuation artifacts may decrease the specificity of the test. These artifacts can be corrected with an attenuation correction. We prospectively included 70 patients who underwent myocardial perfusion SPECT with (IRAC) and without (IRNC) attenuation correction using transmission CT imaging integrated in the acquisition system in patients with low prevalence of CAD. Automatic quantitative analysis with summed stress score (SSS) and rest (SRS) and summed difference score (SDS) was used as interpretation criteria. The results showed a specificity of 80%for IRAC and 56%for IRNC, a positive predictive value of 40%for IRAC and 23%for IRNC, without any significant change in sensitivity. An unpaired t-test showed no significant difference between the overall population and one where an artifact was corrected for heart rate and breath rate during the acquisition effort, the body mass index, chest and abdomen circumferences, and the ratio of these two parameters. Attenuation correction significantly improves the specificity of myocardial scintigraphy with no significant difference in sensitivity. The majority of corrections were for artifacts from the inferior wall in men. There is no correlation between the anthropomorphic and physiological parameters and the occurrence of an artifact of attenuation corrected with CT data.