Synthesis and antibacterial activity of novel fluoroquinolones containing substituted piperidines

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• 作者：Zhao Dang ; Yushe Yang ; Ruyun Ji ; Shuhua Zhang
• 关键词：Fluoroquinolone ; Antibacterial activity ; Piperidine
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2007
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：15 August 2007
• 卷：17
• 期：16
• 页码：4523-4526
• 文件大小：137 K

摘要

The design and synthesis of new fluoroquinolone antibacterial agents having substituted piperidine rings at the C-7 position are described. Most of the new compounds demonstrated high in vitro antibacterial activity. Several of them exhibited significant activities against Gram-positive organisms, which were more potent than those of gemifloxacin, Linezolid, and vancomycin.