Synthesis of 2-N-substituted benzothiazoles via domino condensation-hetero cyclization process, mediated by copper oxide nanoparticles under ligand-free conditions

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• 作者：G. Satish ; K. Harsha Vardhan Reddy ; K. Ramesh ; K. Karnakar ; Y.V.D. Nageswar ; ^{dryvdnageswar@gmail.com}
• 关键词：2-N-substituted benzothiazole ; Carbon disulfide ; Piperidine ; CuO nanoparticles ; Recyclability
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：16 May, 2012
• 卷：53
• 期：20
• 页码：2518-2521
• 文件大小：3134 K

摘要

A simple and highly practical method for the synthesis of 2-N-substituted benzothiazoles has been developed by using nanocopper oxide as a recyclable catalyst. The present tandem process allows to get access to a wide range of 2-N-substituted benzothiazoles in good to excellent yields by the reaction of 2-iodo aniline with carbon disulfide and piperidine in presence of KOH as a base and DMSO as a solvent under ligand-free conditions.