Advances in approaches to DNA-based diagnostics

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• 作者：Whitcombe ; David ; Newton ; Clive R ; Little ; Stephen
• 关键词：ARMS amplification refractory mutation system ; FRET fluorescence resonance energy transfer ; HANDS homo-tag assisted non-dimer system ; OLA oligonucleotide ligation assay ; PNA peptide nucleic acid ; RRS resonance Raman scattering
• 刊名：Current Opinion in Biotechnology
• 出版年：1998
• 期刊代码：23_09581669
• 类别：imm
• 出版时间：December, 1998
• 卷：9
• 期：6
• 页码：602-608
• 文件大小：912 K

摘要

The most tangible advances in DNA diagnostics during the past year have been in enhancing existing techniques to simplify their use and improve throughput. This has led to simplified genotyping methods using homogeneous analysis coupled with spectral data output. Miniaturisation and increased throughput have also been achieved through improvements in DNA chip technology.