FK506 facilitates chemical kindling induced by pentylenetetrazole in rats

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• 作者：Suzuki ; Katsuaki ; Omura ; Shinichi ; Ohashi ; Yutaka ; Kawai ; Masayoshi ; Iwata ; Yasuhide ; Tani ; Kunihiko ; et. al.
• 关键词：Kindling ; Pentylenetetrazole ; FK506 ; Calcineurin ; Rat
• 刊名：Epilepsy Research
• 出版年：2001
• 期刊代码：87_09201211
• 类别：med
• 出版时间：September, 2001
• 卷：46
• 期：3
• 页码：279-282
• 文件大小：68.5 K

摘要

To clarify the possible role played by calcineurin in kindling development, we examined the effects of pretreatment with FK506, a selective calcineurin inhibitor, on pentylenetetrazole (PTZ) kindling in rats. FK506 facilitated the speed of kindling induced by repeated administration of 30-mg/kg PTZ, while FK506 did not ameliorate acute seizure manifestations after a single injection of PTZ. Our results suggested that calcineurin might exert an inhibitory effect on PTZ kindling.