Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing

详细信息	查看全文 | 推荐本文 |

• 作者：Deary ; Ian J. ; Hamilton ; Gillian ; Hayward ; Caroline ; Whalley ; Lawrence J. ; Powell ; John ; Starr ; John M. ; et. al.
• 关键词：Nicastrin ; IQ ; Polymorphism ; Intelligence ; Cognition ; Ageing ; Scottish Mental Survey ; Dementia
• 刊名：Neuroscience Letters
• 出版年：2005
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：January 10, 2005
• 卷：373
• 期：2
• 页码：110-114
• 文件大小：71.2 K

摘要

The hypothesis that polymorphisms in the gene for nicastrin (NCSTN) are associated with differences in cognitive level and ageing was tested in 462 relatively healthy surviving participants of the Scottish Mental Survey 1932. None had a history of dementia. They were tested on the Moray House Test of verbal reasoning at age 11 in 1932 and at age 79 between 1999 and 2001. At age 79 they also took tests of non-verbal reasoning, short- and long-term verbal declarative memory, Verbal Fluency, and a short screening test for dementia. Subjects who possessed at least one copy of the NCSTN B haplotype (Hap B) had higher scores on the Moray House Test (a test principally of verbal reasoning) at age 11 (p