Histological examination of PLGA nanospheres for intratracheal drug administration

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• 作者：Kaori Hara ; Hiroyuki Tsujimoto ; Yusuke Tsukada ; C.C. Huang ; Yoshiaki Kawashima ; Masahiro Tsutsumi
• 关键词：Drug delivery system ; PLGA nanosphere ; Intratracheal instillation ; Immuno-histo-chemical staining
• 刊名：International Journal of Pharmaceutics
• 出版年：2008
• 期刊代码：24_03785173
• 类别：pha
• 出版时间：22 May 2008
• 卷：356
• 期：1-2
• 页码：267-273
• 文件大小：1484 K

摘要

Polylactide–glycolide (PLGA) nanospheres were reported as useful pulmonary drug delivery carriers for improving the pharmacological effect of drug. This paper describes the pathological and histological examinations of tissues after intratracheal instillation of drug encapsulated PLGA nanospheres. After intratracheally introducing FITC encapsulated PLGA nanospheres (dispersed in the 0.5 ml saline followed by mixing with an equal volume of air) to a rat, FITC was found existing in the rat's lungs, liver, kidney, brain, spleen and pancreas as demonstrated by immuno-histo-chemical staining with the dye.