• 作者：Alba Naudí ; Mariona Jové ; Victoria Ayala ; Manuel Portero-Otí ; n ; Reinald Pamplona ; ^{reinald.pamplona@mex.udl.cat}
• 关键词：Productos de glicació ; n avanzada ; Dicarbonilos ; Glicació ; n ; Mitocondria
• 刊名：Revista Espa帽ola de Geriatr铆a y Gerontolog铆a
• 出版年：2010
• 期刊代码：pca313_0211139X
• 类别：med
• 出版时间：May-June 2010
• 卷：45
• 期：3
• 页码：156-166
• 文件大小：344 K

Mitochondrial proteins can be modified by glycation reactions from endogenous dicarbonyl compounds such as physiologically generated methylglyoxal and glyoxal. This modification could cause structural and functional changes in the proteins Consequently, dicarbonyl attack of the mitochondrial proteome may be an event leading to mitochondrial dysfunction and thus, to oxidative stress. These protein chemical modifications can play an important role in the physiological aging process and age-associated diseases, where both mitochondrial deffects and increased dicarbonyl concentrations have been found. Future research should address the functional changes in mitochondrial proteins that are the targets for dicarbonyl glycation.