Analyses by GC–MS and GC–MS–MS of the hantzsch synthesis products using hydroxy- and methoxy-aromatic aldehydes

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• 作者：Luis J. Nú ; ñ ; ez-Vergara ; P.A. Navarrete-Encina ; S. Salas ; B. Conde ; J. Carbajo ; J.A. Squella ; C. Camargo
• 关键词：GC&#x2013 ; MS ; GC&#x2013 ; MS&#x2013 ; MS ; Trimethylsilyl C-4 hydroxy- and methoxyphenyl-substituted 1 ; 4-dihydropyridines ; Chromeno[3 ; 4-c]pyridine
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2007
• 期刊代码：65_07317085
• 类别：ch
• 出版时间：9 May 2007
• 卷：44
• 期：1
• 页码：236-242
• 文件大小：568 K

摘要

EI mass spectra of products of the dihydropyridine Hantzsch synthesis using hydroxy and methoxy aldehydes as starting materials are reported. The reaction products (C-4 hydroxy- and methoxyphenyl-1,4-dihydropyridines and chromeno[3,4,c]-pyridines) were derivatized with N-methyl-N-(trimethylsilyl)-trifluoracetamide to be analyzed by gas chromatographic techniques. Fragmentation pathways for 1,4-dihydropyridines and chromeno-pyridines are proposed. The study provides (mainly through MS–MS technique) useful data for the confirmation of the structure of the compounds and also is a valuable tool for further analytical purposes to follow both photostability and reactivity studies with free radicals for these types of compounds.