Brefeldin A, a cytotoxin produced by Paecilomyces sp. and Aspergillus clavatus isolated from Taxus mairei and Torreya grandis
- 作者：Wang ; Jianfeng ; Huang ; Yaojian ; Fang ; Meijuan ; Zhang ; Yongjie ; Zheng ; Zhonghui ; Zhao ; Yufen ; et. al.
- 关键词：Brefeldin A ; Endophytic fungi ; Paecilomyces sp. ; Aspergillus clavatus ; Taxus mairei ; Torreya grandis
- 刊名：FEMS Immunology and Medical Microbiology
- 出版年：2002
- 期刊代码：32_09288244
- 类别：imm
- 出版时间：September 6, 2002
- 卷：34
- 期：1
- 页码：51-57
- 文件大小：418 K
摘要
Paecilomyces sp. and Aspergillus clavatus, which were isolated from Taxus mairei and Torreya grandis from southeast China, produced toxic metabolites when grown in liquid culture. Nuclear magnetic resonance techniques, infrared spectrometry, electrospray ionization mass spectroscopy and X-ray analysis identified brefeldin A, a bioactive metabolite produced by a number of fungal species belonging to the genera Alternaria, Ascochyta, Penicillium, Curvularia, Cercospora and Phyllosticta. This is the first report of the isolation of the cytotoxin from Paecilomyces sp. and A. clavatus. The relevance of brefeldin A to the association between these fungi and their host plants is discussed.