云南省文山州1986年～2015年麻风死亡相关因素研究
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摘要
目的探讨云南省文山州麻风患者的死亡相关因素,为控制麻风流行、降低麻风死亡率提供依据。方法通过收集整理云南省文山州(1986～2015)年3 376例麻风患者的流行病学资料、临床资料,应用SPSS软件进行统计学分析。结果 3 376例麻风患者中死亡916例,占总人数的27.1%,平均死亡年龄为(47.0±20.3)岁,低于当地平均死亡年龄;初发患者死亡率为26.2%,复发患者死亡率为33.5%,复发患者的死亡率高于初发患者;无畸残患者的死亡率为25.8%,畸残患者的死亡率为31.2%,畸残患者的死亡率高于无畸残者;(1986～1997)年麻风患者死亡率为37.7%,(1998～2001)年麻风患者死亡率为27.5%,(2002～2015)年死亡率为11.3%,从1986年到2015年的死亡率逐渐降低;死亡组发病年龄平均为(38.5±18.1)岁,存活组发病年龄平均为(32.0±13.8)岁,死亡组患者的发病年龄大于存活组,且随着发病年龄的增大,死亡率增高;死亡患者治愈组的平均死亡年龄为(47.6±20.8)岁,死亡患者未判愈组的平均死亡年龄为(44.8±18.2)岁,两组间平均死亡年龄无统计学差异(P> 0.05)。结论复发麻风患者的死亡率高于初发患者,有畸残的麻风患者死亡率高于无畸残者,麻风患者的死亡与发病年龄、发病年代有关,发病年龄大的患者死亡率较高,年代较久远的患者发病率高,因此应采取干预措施提高人群对麻风的防范认识以降低麻风的复发率、畸残率,从而降低死亡率。
Objective To explore the death-related factors of leprosy patients in Wenshan Prefecture, Yunnan Province, and provide evidence for controlling leprosy epidemic situation and reducing leprosy mortality. Methods The epidemiological data and clinical data of 3376 leprosy patients in Wenshan Prefecture of Yunnan Province from 1986 to 2015 is collected and analyzed by SPSS software. Results 916 of the 3376 leprosy patients died, accounting for 27.1% of the total number. The average age of death was 47.0±20.3 years old, lower than the local average life span; The mortality of the initial leprosy patients is 26.2%, and the mortality of relapse leprosy patients is 33.5%,the mortality of relapsed patients is higher than that of the initial patients; The mortality of the patients without disability is 25.8%,the mortality of the disability patients is 31.2%,the mortality rate of patients with disability is higher than that of non-distorted patients; The mortality is 37.7% between 1986 and 1997, the mortality is 27.5% between 1998 and 2001, and the mortality is 11.3% between 2002 and 2015,the mortality decreased gradually from 1986 to 2018. The average age of onset in the death group is 38.5±18.1 years old, and the average age of onset in the survival group is 32.0±13.8 years old. The morbidity age of death group was older than that of survival group, and the mortality rate increased with the increase of morbidity age; The average death age of the cured patients is 47.6±20.8 years old, and the average death age of the nonecured death patients is 44.8±18.2 years old., there is no significant difference between the two groups(P > 0.05). Conclusion The mortality of recurrent leprosy patients is higher than the initial patients;The mortality of leprosy patients with disability is higher than that of non-distorted patients; Death of leprosy patients is related to age and age of onset, and the mortality of patients lives long years ago is high. Therefore, measures should be taken to improve the population's awareness of leprosy prevention to reduce the rate of recurrence rate and disability rate in order to reduce mortality.
Objective To explore the death-related factors of leprosy patients in Wenshan Prefecture, Yunnan Province, and provide evidence for controlling leprosy epidemic situation and reducing leprosy mortality. Methods The epidemiological data and clinical data of 3376 leprosy patients in Wenshan Prefecture of Yunnan Province from 1986 to 2015 is collected and analyzed by SPSS software. Results 916 of the 3376 leprosy patients died, accounting for 27.1% of the total number. The average age of death was 47.0±20.3 years old, lower than the local average life span; The mortality of the initial leprosy patients is 26.2%, and the mortality of relapse leprosy patients is 33.5%,the mortality of relapsed patients is higher than that of the initial patients; The mortality of the patients without disability is 25.8%,the mortality of the disability patients is 31.2%,the mortality rate of patients with disability is higher than that of non-distorted patients; The mortality is 37.7% between 1986 and 1997, the mortality is 27.5% between 1998 and 2001, and the mortality is 11.3% between 2002 and 2015,the mortality decreased gradually from 1986 to 2018. The average age of onset in the death group is 38.5±18.1 years old, and the average age of onset in the survival group is 32.0±13.8 years old. The morbidity age of death group was older than that of survival group, and the mortality rate increased with the increase of morbidity age; The average death age of the cured patients is 47.6±20.8 years old, and the average death age of the nonecured death patients is 44.8±18.2 years old., there is no significant difference between the two groups(P > 0.05). Conclusion The mortality of recurrent leprosy patients is higher than the initial patients;The mortality of leprosy patients with disability is higher than that of non-distorted patients; Death of leprosy patients is related to age and age of onset, and the mortality of patients lives long years ago is high. Therefore, measures should be taken to improve the population's awareness of leprosy prevention to reduce the rate of recurrence rate and disability rate in order to reduce mortality.
引文
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[6]黎明,郑道城,刁鑑兴.43例麻风现症病人死亡原因的回顾分析[J].热带医学杂志,2007,7(2):161-162.
[7]李文忠.现代麻风病学[M].上海:上海科学技术出版社,2006:214-230.
[8]许政,祝永刚.40例住院麻风患者治愈后死因分析[J].临床医学研究与实践,2016,1(22):40.
[9]刘峰,刘岭,郭晓荣,等.2006年陕西省疾病监测点居民死亡原因统计分析[J].疾病监测,2008,23(9):589-592.
[10]Sathishkumar D,George R,Daniel D,et al.Clinical profile of childhood-onset psoriasis and prevalence of HLA-Cw6:a hospital-based stdy from India.[J].Postgraduate Medical Journal,2015,91(1076):309-14.
[11]赵辨.中国临床皮肤病学[M].第2版,南京:江苏科学技术出版社,2017:493-45.
[2]龙思宇.2011-2015年中国麻风流行病学特征分析[A].中国麻风防治协会.2017年全国麻风皮肤性病学术年会论文集[C].中国麻风防治协会,2017:5.
[3]余美文,张国成,严良斌,等.2001-2010年中国麻风病流行病学特征分析[J].中华皮肤科杂志,2012,45(6).
[4]中华人民共和国卫生部.中华人民共和国卫生行业标准:麻风病诊断标准(ws291-2018)[S].北京:人民卫生出版社,2018.
[5]杨梨丽,李进岚,刘洁,等.贵州省108例麻风现症患者死因调查[J].皮肤病与性病,2017,(6):461-463.
[6]黎明,郑道城,刁鑑兴.43例麻风现症病人死亡原因的回顾分析[J].热带医学杂志,2007,7(2):161-162.
[7]李文忠.现代麻风病学[M].上海:上海科学技术出版社,2006:214-230.
[8]许政,祝永刚.40例住院麻风患者治愈后死因分析[J].临床医学研究与实践,2016,1(22):40.
[9]刘峰,刘岭,郭晓荣,等.2006年陕西省疾病监测点居民死亡原因统计分析[J].疾病监测,2008,23(9):589-592.
[10]Sathishkumar D,George R,Daniel D,et al.Clinical profile of childhood-onset psoriasis and prevalence of HLA-Cw6:a hospital-based stdy from India.[J].Postgraduate Medical Journal,2015,91(1076):309-14.
[11]赵辨.中国临床皮肤病学[M].第2版,南京:江苏科学技术出版社,2017:493-45.