精准医疗在肿瘤治疗中的应用
摘要
恶性肿瘤一直以来严重威胁着人类健康,近年来,其发病率和致死率逐步上升。随着生物医学的不断发展,分子诊断学和基因组精准筛查技术的进步,加快了人们在基因组层面对疾病的认识。基于上述背景,研究者们提出了"个体化治疗"的概念与模式。主要研究了一种新型的医学概念与医疗模式,即精准医疗。从精准医疗提出的背景,精准医疗的概念,具体实施方法及应用与展望等方面对精准医疗在肿瘤治疗中的应用做了详细的阐述。
引文
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[2] Siegel RL,Miller KD,Jemal A.Cancer Statistics[J].journal for clinicians,2018,67(1):7-30.
[3] Qiu F,Zhao X,Study on the sensitivity of primary tumor cells of patients with cervical cancer to chemotherapeutic combinations[J].J BUON,2018,23(1).
[4] Lawrence MS,Stojanov P,Mermel CH,Robinson JT,Garraway LA,Golub TR,et al.Discovery and saturation analysis of cancer genes across 21 tumour types[J].Nature,2014,505(7484):495-501.
[5] Burstein HJ,Mangu PB,Somerfield MR,Schrag D,Samson D,Holt L,et al.American Society of Clinical Oncology clinical practice guideline update on the use of chemotherapy sensitivity and resistance assays[J].Journal of clinical oncology:official journal of the American Society of Clinical Oncology,2011,29(24):3328-3330.
[6] Schrag D,Garewal HS,Burstein HJ,Samson DJ,Von Hoff DD,Somerfield MR,et al.American Society of Clinical Oncology Technology Assessment:chemotherapy sensitivity and resistance assays[J].Journal of clinical oncology:official journal of the American Society of Clinical Oncology,2004,22(17):3631-3638.
[7] 韦开亮,MTT法体外检测脑胶质瘤对常用化疗药物敏感性研究[D].桂林:桂林医学院,2014.
[8] 喻卫红,王静,王晓彬,李英辉,张烨,王玉名,田雪.恶性肿瘤患者化疗敏感性筛选的临床意义[J].临床肿瘤学杂志,2013,18(09):799-803.
[9] 林群,匡裕康,吴九发.体外肿瘤药敏试验指导非小细胞肺癌个体化新辅助化疗的临床价值[J].临床合理用药杂志,2015,8(18):97-98.
[10]米彦军,张传钊,符立梧.肿瘤药敏试验指导个体化治疗的研究进展[J].药学学报,2009,44(11):1187-1192.