黄芪多糖对猪瘟疫苗免疫效果影响的Meta分析
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摘要
为了系统评价黄芪多糖对猪瘟疫苗免疫效果的影响,通过检索数据库资料,纳入有关黄芪多糖对猪瘟疫苗免疫效果影响的随机对照试验(共纳入11个对照试验,样本量为244头猪),利用Cochrane Reviewer′s Handbook 5.0评价标准对试验质量进行评价,并使用Revman 5.3进行统计分析。结果显示:黄芪多糖可显著提高血液中的猪瘟抗体水平,同时提高其血液中的IL-2含量,优于单纯免疫组。表明黄芪多糖可通过提高机体的体液免疫和细胞因子水平来增强猪瘟疫苗的免疫效果,效果确切,值得推广应用。
In order to systematically evaluate the effect of Astragalus polysaccharide on the immune ef fect of classical swine fever(SFV) vaccine, randomized controlled trials on the effect of Astragalus polysaccharide on the immune effect of CSF vaccine were included by searching the database data(a total of 11 controlled trials were included,with a sample size of 244 pigs). The Cochrane Reviewer′s Handbook 5.0 evaluation standard was used to evaluate its quality,and Revman 5.3 was used for statistical analysis. The results showed that Astragalus polysaccharide can significantly increase the antibody level of CSF in the blood and increase the IL-2 content in the blood,which were superior to the pure immunization group. The results indicated that Astragalus polysaccharide can enhance the immune effect of CSF vaccine by improving the levels of humoral immunity and cytokine,its effect is exact,can be promoted and applied.
In order to systematically evaluate the effect of Astragalus polysaccharide on the immune ef fect of classical swine fever(SFV) vaccine, randomized controlled trials on the effect of Astragalus polysaccharide on the immune effect of CSF vaccine were included by searching the database data(a total of 11 controlled trials were included,with a sample size of 244 pigs). The Cochrane Reviewer′s Handbook 5.0 evaluation standard was used to evaluate its quality,and Revman 5.3 was used for statistical analysis. The results showed that Astragalus polysaccharide can significantly increase the antibody level of CSF in the blood and increase the IL-2 content in the blood,which were superior to the pure immunization group. The results indicated that Astragalus polysaccharide can enhance the immune effect of CSF vaccine by improving the levels of humoral immunity and cytokine,its effect is exact,can be promoted and applied.
引文
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[4]孟兴华,张雪琪,靳媛媛,等.黄芪多糖与香茹多糖协同应用对仔猪免疫功能的影响[J].饲料研究,2017(3):32-34.
[5]万思敬.黄芪多糖稀释液对猪瘟疫苗免疫效果的影响[J].中国动物保健,2017(11):73-74.
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[8]马霞,李利红,刘永录,等.黄芪多糖对猪瘟活疫苗免疫效果的影响[J].郑州牧业工程高等专科学校学报,2013(3):12-13.
[9]姚敬明,孟帆,王娟萍,等.黄芪多糖对猪瘟疫苗体液免疫和细胞免疫的影响[J].畜牧兽医科技信息,2016(9):15-18.
[10]黄保平,刘银宝,刘玉华.黄芪多糖对断奶仔猪生产性能与猪瘟疫苗免疫效果的影响[J].安徽农业科学,2014,42(17):5 493-5 494,5 496.
[11]杜立中,马霞,刘永录,等.黄芪多糖对猪瘟活疫苗免疫应答的佐剂作用[J].河南农业科学,2014,43(9):156-159.
[12]邵珊,王贵平,李春玲,等.黄芪多糖和白花蛇舌草多糖对猪繁殖与呼吸综合征灭活疫苗免疫猪T细胞亚群及抗体水平的影响[J].中国兽医学报,2011,31(8):1196-1199.
[2]董利民,代长云,阮征.黄芪多糖对猪瘟疫苗免疫效果的影响[J].当代畜牧,2016(32):118-119.
[3]邱树磊,张斌,陈晓兰,等.中药联合猪瘟疫苗免疫对猪瘟抗体水平及血常规指标的影响[J].畜牧与兽医,2016,48(12):85-89.
[4]孟兴华,张雪琪,靳媛媛,等.黄芪多糖与香茹多糖协同应用对仔猪免疫功能的影响[J].饲料研究,2017(3):32-34.
[5]万思敬.黄芪多糖稀释液对猪瘟疫苗免疫效果的影响[J].中国动物保健,2017(11):73-74.
[6]王超锋,王远微.黄芪多糖对猪瘟弱毒疫苗的免疫增强作用[J].四川畜牧兽医,2013,40(4):19-20.
[7]杜继红,高亚军,王海良,等.黄芪多糖粉对猪瘟疫苗免疫效果及生长性能的影响[J].中国畜牧杂志,2013(22):65-68.
[8]马霞,李利红,刘永录,等.黄芪多糖对猪瘟活疫苗免疫效果的影响[J].郑州牧业工程高等专科学校学报,2013(3):12-13.
[9]姚敬明,孟帆,王娟萍,等.黄芪多糖对猪瘟疫苗体液免疫和细胞免疫的影响[J].畜牧兽医科技信息,2016(9):15-18.
[10]黄保平,刘银宝,刘玉华.黄芪多糖对断奶仔猪生产性能与猪瘟疫苗免疫效果的影响[J].安徽农业科学,2014,42(17):5 493-5 494,5 496.
[11]杜立中,马霞,刘永录,等.黄芪多糖对猪瘟活疫苗免疫应答的佐剂作用[J].河南农业科学,2014,43(9):156-159.
[12]邵珊,王贵平,李春玲,等.黄芪多糖和白花蛇舌草多糖对猪繁殖与呼吸综合征灭活疫苗免疫猪T细胞亚群及抗体水平的影响[J].中国兽医学报,2011,31(8):1196-1199.