仿生介孔二氧化硅用于高效液相色谱拆分手性化合物
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摘要
仿生介孔硅是以有机物作为模板,可有效复刻模板的独特形貌,从而得到其相同或相似结构孔径的介孔硅。本文从仿生的观点出发,从蟹壳中提取得到几丁质膜,将其用作模板制备了仿生手性向列型介孔二氧化硅,并用其制备了液相色谱柱,进行了手性化合物拆分实验。结果表明,该色谱固定相对10个手性化合物有一定的手性分离效果。
The biomimetic mesoporous silica is a mesoporous silica,which using organic silicane as a template that can effectively reproduce the unique morphology of the template, thereby obtaining the same or similar mesoporous structure with mesoporous silica. In this paper, bionic mesoporous silica was prepared from the biomimetic point of view,and the bionic chiral nematic mesoporous silica was prepared by extracted the chitin film from the crab shell as a template,and then the bionic chiral nematic mesoporous silica was used to prepare liquid chromatography column. The prepared column was used for the separation of chiral compounds in the high performance liquid chromatograph. The experimental results showed that the chromatographic stationary phase has a certain chiral separation effect to 10 chiral compounds.
The biomimetic mesoporous silica is a mesoporous silica,which using organic silicane as a template that can effectively reproduce the unique morphology of the template, thereby obtaining the same or similar mesoporous structure with mesoporous silica. In this paper, bionic mesoporous silica was prepared from the biomimetic point of view,and the bionic chiral nematic mesoporous silica was prepared by extracted the chitin film from the crab shell as a template,and then the bionic chiral nematic mesoporous silica was used to prepare liquid chromatography column. The prepared column was used for the separation of chiral compounds in the high performance liquid chromatograph. The experimental results showed that the chromatographic stationary phase has a certain chiral separation effect to 10 chiral compounds.
引文
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[2] U Woiwode,R J Reischl,S Buckenmaier et al. Anal. Chem.,2018,90(13).
[3]涂鸿盛,范军,谭艺等.色谱,2014,32(5):452~457.
[4] T Wang,H Yang,R Qiu et al. Anal. Chim. Acta,2016,944:70~77.
[5]戴荣继,王慧婷,孙维维等.色谱,2016,34(1):34~43.
[6] Q Yue,Q Huang,Y Y Gao et al. Inorg. Chim. Acta,2016,443:110~117.
[7]傅若农.色谱分析概论(第2版).北京:化学工业出版社,2005,163~168.
[8]傅若农.色谱,2016,34(1):2~3.
[9]李宁,潘晓玲,黄光亮等.化学学报,2011,69(8):981~986.
[10] J Shen,Y Okamoto. Chem. Rev.,2016,116(3):1094~1138.
[11] X Yao,H Zheng,Y Zhang et al. Anal. Chem.,2016,88(9):4955~4964.
[12] P Ding,B S Chang,G Y Qing et al. Sci. China Chem.,2014,57(11):1492~1506.
[13]党文修,韩书华,侯万国等.化学通报,2004,67:w010.
[14]付永昌,刘强,柳清菊.材料导报,2008,22(S3):272~275.
[15]王静,刘爽,张春,徐辉碧等.化学进展,2011,23(4):669~678.
[16]王生杰,蔡庆伟,杜明轩等.化学进展,2015,27(2/3):229~241.
[17] K Todoroki,Y Ishii,T Ide et al. Anal. Chim. Acta,2015,882:101~111.
[18] Y Ke,L L Ong,W M Shih et al. Science,2012,338(6111):1177~1183.
[19] H O Fabritius,C Sachs,P R Triguero et al. Adv. Mater.,2014,21(4):391~400.
[20] T D Nguyen,M J Maclachlan. Adv. Opt. Mater.,2015,2(11):1031~1037.
[21] R N Tharanathan,F S Kittur. Crit. Rev. Food Technol.,2003,43(1):61~87.