IL-34与临床疾病关系的研究进展
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摘要
白细胞介素-34作为新型细胞因子近几年已受到广泛热议,其作为促炎因子参与了多种疾病,尤其是自身免疫性疾病的发生与发展。但白细胞介素-34在疾病中的具体机制仍有待深入研究,因此,总结白细胞介素-34与临床疾病的关系,对白细胞介素-34的机制研究和寻求相关临床疾病的潜在治疗靶点具有重要意义。
Interleukin-34, as a novel cytokine, has been widely discussed in recent years. As a proinflammatory cytokine, interleukin-34 is involved in the occurrence and development of various diseases, especially autoimmune diseases. However, the specific mechanism of interleukin-34 in diseases remains to be further studied. Therefore,it is of great significance to summarize the relationship between interleukin-34 and clinical diseases, to study the mechanism of interleukin-34 and to seek potential therapeutic targets for related clinical diseases.
Interleukin-34, as a novel cytokine, has been widely discussed in recent years. As a proinflammatory cytokine, interleukin-34 is involved in the occurrence and development of various diseases, especially autoimmune diseases. However, the specific mechanism of interleukin-34 in diseases remains to be further studied. Therefore,it is of great significance to summarize the relationship between interleukin-34 and clinical diseases, to study the mechanism of interleukin-34 and to seek potential therapeutic targets for related clinical diseases.
引文
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[31]SELANDER K,LEHENKARI P,V??N?NEN H.The effects of bisphosphonates on the resorption cycle of isolated osteoclasts[J].Calcif Tissue Int,1994,55(5):368-375.
[32]CHEN Z,BUKI K,V??R?NIEMI J,et al.The critical role of IL-34 in osteoclastogenesis[J].PLoS ONE,2011,6(4):DOI:10.1371/journal.pone.0018689.
[33]SéGALINY A,MOHAMADI A,DIZIER B,et al.Interleukin-34promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment[J].Cancer,2015,137(1):73-85.
[34]CICCIA F,ALESSANDRO R,RODOLICO V,et al.IL-34 is overexpressed in the inflamed salivary glands of patients with sjogren’s syndrome and is associated with the local expansion of pro-inflammatory CD14(bright)CD16+monocytes[J].Rheumatology(Oxford),2013,52(6):1009-1017.
[35]LI Z,JIN D,WU Y,et al.Increased serum interleukin-34 in patients with coronary artery disease[J].Int Med Res,2012,40(5):1866-1870.
[36]CHANG S,CHOI B,CHOI J,et al.Baseline serum interleukin-34levels independently predict radiographic progression in patients with rheumatoid arthritis[J].Rheumatol Int,2015,35(1):71-79.
[37]YU G,BING Y,ZHU S,et al.Activation of the interleukin-34inflammatory pathway in response to influenza a virus infection[J].Med Sci,2015,349(2):145-150.
[38]CECCHINI M,DOMINGUEZ M,MOCCI S,et al.Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse[J].Development,1994,120(6):1357-1372.
[39]GINHOUX F,TACKE F,ANGELI V,et al.Langerhans cells arise from monocytes in vivo[J].Nat Immunol,2006,7(3):265-273.
[40]DAI X,RYAN G,HAPEL A,et al.Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis,mononuclear phagocyte deficiency,increased primitive progenitor cell frequencies,and reproductive defects[J].Blood,2002,99(1):111-120.
[2]ZWICKER S,MARTINEZ G,BOSMA M,et al.Interleukin 34:a new modulator of human and experimental inflammatory bowel disease[J].Clin Sci,2015,129(3):281-290.
[3]VIVINUS-NéBOT M,FRIN-MATHY G,BZIOUECHE H,et al.Functional bowel symptoms in quiescent inflammatory bowel diseases:role of epithelial barrier disruption and low-grade inflammation[J].Gut,2014,63(5):744-752.
[4]HE F,PENG J,DENG X,et al.Mechanisms of tumor necrosis factor-alpha-induced leaks in intestine epithelial barrier[J].Cytokine,2012,59(2):264-272.
[5]BAUD’HUIN M,RENAULT R,CHARRIER C,et al.Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis[J].Pathol,2010,221(1):77-86.
[6]EDA H,SHIMADA H,BEIDLER D,et al.Proinflammatory cytokines,IL-1βand TNF-α,induce expression of interleukin-34mRNA via JNK-and p44/42 MAPK-NF-κB pathway but not p38pathway in osteoblasts[J].Rheumatol Int,2011,31(11):1525-1530.
[7]HWANG S,CHOI B,KANG S,et al.Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis[J].Arthritis Res Ther,2012,14(1):R14.
[8]DENNING T,NORRIS B,MEDINA-CONTRERAS O,et al.Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio,source of mouse strain,and regional localization[J].Immunol,2011,187(2):733-747.
[9]FRANZèE,MONTELEONE I,CUPI M,et al.Interleukin-34sustains inflammatory pathways in the gut[J].Clin Sci,2015,129(3):271-280.
[10]CHENG S,TANG H,REN J,et al.Interleukin-34 inhibits hepatitis B virus replication in vitro and in vivo[J].PLoS ONE,2017,12(6):DOI:10.1371/journal.pone.0179605.
[11]PREISSER L,MIOT C,LE GUILLOU-GUILLEMETTE H,et al.IL-34 and macrophage colony-stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells[J].Hepatology,2014,60(6):1879-1890.
[12]ZHOU S,HU Z,ZHOU Z,et al.miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis[J].Hepatology,2016,63(5):1560-1575.
[13]NOY R POLLARD J.Tumor-associated macrophages:from mechanisms to therapy[J].Immunity,2014,41(1):49-61.
[14]QIAN B,POLLARD J.Macrophage diversity enhances tumor progression and metastasis[J].Cell,2010,141(1):39-51.
[15]CHEMEL M,LE GOFF B,BRION R,et al.Interleukin 34expression is associated with synovitis severity in rheumatoid arthritis patients[J].Ann Rheum Dis,2012,71(1):150-154.
[16]MOON S,HONG Y,JU J,et al.Increased levels of interleukin 34in serum and synovial fluid are associated with rheumatoid factor and anticyclic citrullinated peptide antibody titers in patients with rheumatoid arthritis[J].Rheumatol,2013,40(11):1842-1849.
[17]TIAN Y,SHEN H,XIA L,et al.Elevated serum and synovial fluid levels of interleukin-34 in rheumatoid arthritis:possible association with disease progression via interleukin-17production[J].Interferon Cytokine Res,2013,33(7):398-401.
[18]YANG S,JIANG S,WANG Y,et al.Interleukin 34 upregulation contributes to the increment of MicroRNA 21 expression through STAT3 activation associated with disease activity in rheumatoid arthritis[J].Rheumatol,2016,43(7):1312-1319.
[19]CHEMEL M,BRION R,SEGALINY A,et al.Bone morphogenetic protein 2 and transforming growth factorβ1inhibit the expression of the proinflammatory cytokine IL-34 in rheumatoid arthritis synovial fibroblasts[J].Pathol,2017,187(1):156-162.
[20]CHANG E,LEE S,SONG Y,et al.IL-34 is associated with obesity,chronic inflammation,and insulin resistance[J].Clin Endocrinol Metab,2014,99(7):E1263-E1271.
[21]ZORENA K,JACHIMOWICZ-DUDA O,W??P.The cut-off value for interleukin 34 as an additional potential inflammatory biomarker for the prediction of the risk of diabetic complications[J].Biomarkers,2016,21(3):276-282.
[22]BAGHDADI M,WADA H,NAKANISHI S,et al.ChemotherapyInduced IL-34 enhances immunosuppression by tumor-associated macrophages and mediates survival of chemoresistant lung cancer cells[J].Cancer Res,2016,76(20):6030-6042.
[23]CASTELLS M,THIBAULT B,DELORD J,et al.Implication of tumor microenvironment in chemoresistance:tumor-associated stromal cells protect tumor cells from cell death[J].Int J Mol Sci,2012,13(8):9545-9571.
[24]KARIN M,CAO Y,GRETEN F,et al.NF-kappaB in cancer:from innocent bystander to major culprit[J].Nat Rev Cancer,2002,2(4):301-310.
[25]BAEK J,ZENG R,WEINMANN-MENKE J,et al.IL-34mediates acute kidney injury and worsens subsequent chronic kidney disease[J].Clin Invest,2015,125(8):3198-3214.
[26]PELES E,SCHLESSINGER J,GRUMET M.Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta:implications for intercellular signaling[J].Trends Biochem Sci,1998,23(4):121-124.
[27]LI Y,MILNER P,CHAUHAN A,et al.Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity[J].Science,1990,250(4988):1690-1694.
[28]PELES E,NATIV M,CAMPBELL P,et al.The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin[J].Cell,1995,82(2):251-260.
[29]MILEV P,CHIBA A,H?RING M,et al.High affinity binding and overlapping localization of neurocan and phosphacan/proteintyrosine phosphatase-zeta/beta with tenascin-R,amphoterin,and the heparin-binding growth-associated molecule[J].Biol Chem,1998,273(12):6998-7005.
[30]WEI S,NANDI S,CHITU V,et al.Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1receptor-mediated regulation of myeloid cells[J].Leukoc Biol,2010,88(3):495-505.
[31]SELANDER K,LEHENKARI P,V??N?NEN H.The effects of bisphosphonates on the resorption cycle of isolated osteoclasts[J].Calcif Tissue Int,1994,55(5):368-375.
[32]CHEN Z,BUKI K,V??R?NIEMI J,et al.The critical role of IL-34 in osteoclastogenesis[J].PLoS ONE,2011,6(4):DOI:10.1371/journal.pone.0018689.
[33]SéGALINY A,MOHAMADI A,DIZIER B,et al.Interleukin-34promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment[J].Cancer,2015,137(1):73-85.
[34]CICCIA F,ALESSANDRO R,RODOLICO V,et al.IL-34 is overexpressed in the inflamed salivary glands of patients with sjogren’s syndrome and is associated with the local expansion of pro-inflammatory CD14(bright)CD16+monocytes[J].Rheumatology(Oxford),2013,52(6):1009-1017.
[35]LI Z,JIN D,WU Y,et al.Increased serum interleukin-34 in patients with coronary artery disease[J].Int Med Res,2012,40(5):1866-1870.
[36]CHANG S,CHOI B,CHOI J,et al.Baseline serum interleukin-34levels independently predict radiographic progression in patients with rheumatoid arthritis[J].Rheumatol Int,2015,35(1):71-79.
[37]YU G,BING Y,ZHU S,et al.Activation of the interleukin-34inflammatory pathway in response to influenza a virus infection[J].Med Sci,2015,349(2):145-150.
[38]CECCHINI M,DOMINGUEZ M,MOCCI S,et al.Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse[J].Development,1994,120(6):1357-1372.
[39]GINHOUX F,TACKE F,ANGELI V,et al.Langerhans cells arise from monocytes in vivo[J].Nat Immunol,2006,7(3):265-273.
[40]DAI X,RYAN G,HAPEL A,et al.Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis,mononuclear phagocyte deficiency,increased primitive progenitor cell frequencies,and reproductive defects[J].Blood,2002,99(1):111-120.