Sd~a抗原研究进展
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摘要
<正>1967年Macvie和Renton等同时报道了一个新发现的抗原Sda。首先是从先证者Sidney Smith血浆中发现了抗Sda,然后证明了这是一个新的抗原。原名使用是先证者名字缩写,ISBT命名为Sda,编号901012,属于系列抗原中的高频抗原。Sda抗原就是原来的多凝聚红细胞Cad抗原。1 基因Sda抗原的基因位点在17号染色体,17q21.23,基因名B4GALNT2,或称GALGT2,基因编号:124872,
Sd~a antigen is a high frequency antigen(901012) in the "series" of antigens,and is a red blood cell antigen associated with GPA/GPB.Sd~a antigen belongs to glycan chain antigen.It is not only expressed on erythrocyte membrane,but also on tissue and cell.It exists in urine in a free state.The free Sd~a antigen in urine is expressed on Tamm-Horsfall protein.At present,this antigen has met the requirements of a "system" antigen and is likely to become the next system antigen.
Sd~a antigen is a high frequency antigen(901012) in the "series" of antigens,and is a red blood cell antigen associated with GPA/GPB.Sd~a antigen belongs to glycan chain antigen.It is not only expressed on erythrocyte membrane,but also on tissue and cell.It exists in urine in a free state.The free Sd~a antigen in urine is expressed on Tamm-Horsfall protein.At present,this antigen has met the requirements of a "system" antigen and is likely to become the next system antigen.
引文
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[16] 刘芸,陆敏,徐姿,等.多凝集红细胞的研究进展[J].临床血液学杂志,2016,29(6):215-217.
[17] 方莹,李树中,李凌波.forssman血型系统[J].临床血液学杂志,2016,29(2):171-174.
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[19] 倪强,李树中,雒晶,等.GIL抗原研究进展[J].临床血液学杂志,2017,30(10):812-814.
[20] 俞黎娅,李树中,雒晶晶,等.VEL血型抗原研究进展[J].临床血液学杂志,2018,31(2):161-163.
[21] 刘芸,李树中,李凌波,等.AUG血型抗原研究进展[J].临床血液学杂志,2018,31(6):485-490.
[22] 范春丽,李树中,李中华,等.P1PK血型抗原研究进展[J].临床血液学杂志,2018,31(8):643-64.
[2] Guo X,Wang X,Liang B,et al.Molecular Cloning of the B4GALNT2 Gene and Its Single Nucleotide Polymorphisms Association with Litter Size in Small Tail Han Sheep[J].Animals(Basel),2018,8:E160.
[3] Groux-Degroote S,Schulz C,Cogez V1,et al.The extended cytoplasmic tail of the human B4GALNT2 is critical for its Golgi targeting and post-Golgi sorting[J].FEBS J,2018,285:3442-3463.
[4] Byrne G,Ahmad-Villiers S,Du Z,et al.B4GALNT2 and xenotransplantation:A newly appreciated xenogeneic antigen[J].Xenotransplantation,2018,25:e12394.
[5] Zhao C,Cooper DKC,Dai Y,et al.The Sda and Cad glycan antigens and their glycosyltransferase,β1,4GalNAcT-II,in xenotransplantation[J].Xenotransplantation,2018,25:e12386.
[6] Vallier M,Abou Chakra M,Hindersin L,et al.Evaluating the maintenance of disease-associated variation at the blood group-related gene B4galnt2 in house mice[J].BMC Evol Biol,2017,17:187.
[7] Martens GR,Reyes LM,Li P,et al.Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2,and SLA Class I Knockout Pigs[J].Transplantation,2017,101:e86-e92.
[8] Thomas PJ,Xu R,Martin PT.B4GALNT2 (GALGT2) Gene Therapy Reduces Skeletal Muscle Pathology in the FKRP P448L Mouse Model of Limb Girdle Muscular Dystrophy 2I[J].Am J Pathol,2016,186:2429-2448.
[9] Byrne G,Ahmad-Villiers S,Du Z,et al.B4GALNT2 and xenotransplantation:A newly appreciated xenogeneic antigen[J].Xenotransplantation,2018,25:e12394.
[10] Geoff Daniels.Human Blood Groups[M].3rd edition.A John Wiley & Sons,Ltd,Publication,2013:505-511.
[11] Reid,ME,LomasFrancis,C.The blood group antigen[M].Academic Press is an imprint of Elsevier,2012:685-687.
[12] 朱自严,译.人类血型[M].2版.科学出版社,2007:619-627.
[13] Vallier M,Abou Chakra M,Hindersin L,et al.Evaluating the maintenance of disease-associated variation at the blood group-related gene B4galnt2 in house mice[J].BMC Evol Biol,2017,17:187.
[14] Rausch P,Steck N,Suwandi A,et al.Expression of the Blood-Group-Related Gene B4galnt2 Alters Susceptibility to Salmonella Infection[J].PLoS Pathog,2015,11:e1005008.
[15] 徐姿,李树中,卞洁,等.红细胞血型抗原的研究进展[J].临床血液学杂志,2016,29(4):345-350.
[16] 刘芸,陆敏,徐姿,等.多凝集红细胞的研究进展[J].临床血液学杂志,2016,29(6):215-217.
[17] 方莹,李树中,李凌波.forssman血型系统[J].临床血液学杂志,2016,29(2):171-174.
[18] 张志琴,张黎雯,谢怡萍,等.Duffy血型系统抗原研究进展[J].临床血液学杂志,2017,30(4):327-330.
[19] 倪强,李树中,雒晶,等.GIL抗原研究进展[J].临床血液学杂志,2017,30(10):812-814.
[20] 俞黎娅,李树中,雒晶晶,等.VEL血型抗原研究进展[J].临床血液学杂志,2018,31(2):161-163.
[21] 刘芸,李树中,李凌波,等.AUG血型抗原研究进展[J].临床血液学杂志,2018,31(6):485-490.
[22] 范春丽,李树中,李中华,等.P1PK血型抗原研究进展[J].临床血液学杂志,2018,31(8):643-64.