摘要
中药功效是药物作用于人体后产生的治疗作用,中药药性是功效作用的进一步概括,功效与药性之间存在必然的内在关系。该文提出以药性组合为基本单位,通过"药性组合-中药作用靶标-生物网络模块-功效"的研究模式,在整体层次上发现药性组合与中药功效、药效间的关系。研究表明,温辛肝组合通过参与脂质代谢、血液凝固、血小板活化、血红素氧化、血小板脱粒、细胞凋亡、炎症反应等生命过程来达到抗肿瘤、抗血栓、抗心肌缺血和抗炎等药理药效,从而发挥其活血行气的功效。
The efficacy of traditional Chinese medicine is the therapeutic effect of the drug on the body. The nature of traditional Chinese medicine is a further generalization of the effect of efficacy,and there is an intrinsic relationship between efficacy and nature of traditional Chinese medicine. In this study,the nature-effect relationship is found on the whole level,through the research mode of " nature combination-targets of traditional Chinese medicine-modules of protein interaction network-efficiency". The results showed that the warm-pungent-liver protein interaction network mainly participated in lipid catabolic process,blood coagulation,platelet activation,heme oxidation,platelet degranulation,apoptotic process,acute inflammatory response to exert the effect of anti-tumor,antithrombotic,anti-myocardial ischemia and anti-inflammatory.
引文
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