乌梅丸加减对寒热错杂型慢性浅表性胃炎患者PGⅠ、PGⅡ、GEDPRO-CG的影响分析
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摘要
[目的]分析乌梅丸方加减论治寒热错杂型慢性浅表性胃炎对证候积分、胃蛋白酶原(PG)及脾胃系疾病PRO量表慢性胃炎模块(GEDPRO-CG)评分的影响。[方法]随机抽取94例于2015年12月～2017年3月入院治疗的寒热错杂型慢性浅表性胃炎患者,按电脑数字表法随机分组,各47例,施予西药常规治疗者作对照组,施予乌梅丸方加减论治者作试验组,回顾性对比分析其证候积分、PG及GEDPRO-CG评分。[结果]治疗后,试验组证候总积分是(8.11±3.27)分,低于对照组(11.25±3.47)分,差异有统计学意义(P<0.05);试验组PGⅠ为(117.33±49.20)μg/ml,高于对照组(100.25±47.29)μg/ml,差异有统计学意义(P<0.05);试验组GEDPRO-CG评分低于对照组,差异有统计学意义(P<0.05)。[结论]于寒热错杂型慢性浅表性胃炎患者中施予乌梅丸方加减论治有助于改善证候积分、PG水平及GEDPRO-CG评分,值得推广。
[Objective]To analyze the effect of Wumei pills concoctions on the treatment of chronic superficial gastritis complicated with cold and heat syndrome scores,pepsinogen(PG)and stomach disease(PRO)scale chorinc gastritis module(GEDPRO-CG).[Methods]94patients suffered from chronic superficial gastritis complicated with cold and heat from December 2015 to March 2017 in our hospital were randomly selected,and randomly divided into control group and experimental group according to computergenerated number table method.Each group has 47 patients,control group was treated with western medicine,and the experimental group was treated with Wumei pill prescription plus or minus treatment.A retrospective comparative analysis was made of their syndrome scores,PG and GEDPRO-CG scores.[Results]After treatment,the total score of the experimental group syndrome was(8.11±3.27),which was lower than that of the control group(11.25±3.47),with statistically significant(P<0.05);(2)The experimental group was(117.33±49.20)μg/ml,which was higher than control group that was(100.25±47.29)μg/ml,with statistically significant(P<0.05);(3)The score of the experimental group of GEDPRD-CG was lower than that of control group,with statistically significant(P<0.05).[Conclusion]The application of Wumei Pills in patients with chronic superficial gastritis complicated with cold and heat can help to improve syndrome score,PG level and GEDPRO-CG score,which is worthy of promotion.
[Objective]To analyze the effect of Wumei pills concoctions on the treatment of chronic superficial gastritis complicated with cold and heat syndrome scores,pepsinogen(PG)and stomach disease(PRO)scale chorinc gastritis module(GEDPRO-CG).[Methods]94patients suffered from chronic superficial gastritis complicated with cold and heat from December 2015 to March 2017 in our hospital were randomly selected,and randomly divided into control group and experimental group according to computergenerated number table method.Each group has 47 patients,control group was treated with western medicine,and the experimental group was treated with Wumei pill prescription plus or minus treatment.A retrospective comparative analysis was made of their syndrome scores,PG and GEDPRO-CG scores.[Results]After treatment,the total score of the experimental group syndrome was(8.11±3.27),which was lower than that of the control group(11.25±3.47),with statistically significant(P<0.05);(2)The experimental group was(117.33±49.20)μg/ml,which was higher than control group that was(100.25±47.29)μg/ml,with statistically significant(P<0.05);(3)The score of the experimental group of GEDPRD-CG was lower than that of control group,with statistically significant(P<0.05).[Conclusion]The application of Wumei Pills in patients with chronic superficial gastritis complicated with cold and heat can help to improve syndrome score,PG level and GEDPRO-CG score,which is worthy of promotion.
引文
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[15]杨月花,刘全中,丁靖,等.乌梅丸治疗糖尿病胃轻瘫寒热错杂型的临床疗效观察[J].广州中医药大学学报,2016,33(1):12-16.
[16]肖定洪,黄智萍,张美荣,等.原发性胆汁反流性胃炎患者中医体质特点的病例对照研究[J].中国中西医结合消化杂志,2017,25(11):820-822,827.
[17]Chu X,Liu X,Qiu J,et al.Protection of Astragalus Polysaccharides and Codonopsis Pilosula Polysaccharides on Alveolar Macrophage Phagocytosis of Chronic Obstructive Pulmonary Disease Mice With PM2.5Inhalation[J].Chest,2016,149(4):A382-A382.
[18]Iguchi M,Kato J,Fukatsu K,et al.Serum pepsinogen levels can quantify the risk of development of metachronous gastric cancer after endoscopic resection[J].Inter J Cancer,2016,139(5):1150-1156.
[19]Tang CW,Feng WM,Bao Y,et al.Spleen-preserving Distal Pancreatectomy or Distal Pancreatectomy With Splenectomy?:Perioperative and Patient-reported Outcome Analysis[J].J Clin Gastroenterol,2014,48(7):e62.
[20]Matsukuma K,Gui D,Olson KA,et al.OsmoPrep-associated Gastritis:A Histopathologic Mimic of Iron Pill Gastritis and Mucosal Calcinosis[J].Am J Surg Pathol,2016,40(11):1550-1550.
[2]林柳兵,阙任烨,沈艳婷,等.慢性浅表性胃炎的中西医研究进展[J].陕西中医,2016,37(8):1099-1101.
[3]中华医学会消化病学分会,房静远,刘文忠,等.中国慢性胃炎共识意见(2012年,上海)[J].中华消化杂志,2013,18(1):182-184.
[4]黄穗平,黄绍刚.慢性浅表性胃炎中医诊疗共识意见解读[C]//广东省中医、中西医结合脾胃消化病学术会议.2010.
[5]郑筱萸.中药新药临床研究指导原则[M].中国医药科技出版社,2002.
[6]刘凤斌,车晓璐.中华脾胃系疾病患者报告结局量表慢性胃炎模块的反应度研究[C]//世界中医药学会联合会消化病专业委员会消化病国际学术大会.2013.
[7] Conces MR,Arnold CA,Baker PB,et al.A Strategy for Helicobacter Immunohistochemistry Utilization in Pediatric Practice:Insights From Morphologic and CostBenefit Analyses[J].Am J Clin Pathol,2016,146(5):611-617.
[8]孟红艳,马宏博,张光波,等.中医药治疗慢性浅表性胃炎辨证用药规律分析[J].中国医药导报,2016,13(7):84-86.
[9] StyczeńM,Szpor J,Demczuk S,et al.Karyometric Comparison of Splenic and Gastric Marginal Zone Lymphomas[J].Ana Cell Pathol,2016,35(4):297-303.
[10]Chen J,Chen JS,Xie K,et al.Abstract 5405:Comprehensive analysis of long non-coding RNAs in human stomach adenocarcinoma molecular subtypes[J].Cancer Research,2017,77(13Supplement):5405-5405.
[11]王欢,李成光,李林.慢性浅表性胃炎的中医证型分布规律研究[J].辽宁中医杂志,2015,42(8):1390-1393.
[12]李赛莲,许保,陈正义,等.枫蓼肠胃康胶囊联合多潘立酮治疗慢性萎缩性胃炎伴肠上皮化生的临床研究[J].中国中西医结合消化杂志,2018,26(11):907-910,914.
[13]李淑红,刘华一,唐艳萍,等.浅析“木郁达之”[J].浙江中医药大学学报,2017,41(2):120-123.
[14]王佳林.乌梅丸治疗溃疡性结肠炎的疗效观察及对血清IL-4和IL-8水平的影响[J].海南医学院学报,2014,20(1):80-82.
[15]杨月花,刘全中,丁靖,等.乌梅丸治疗糖尿病胃轻瘫寒热错杂型的临床疗效观察[J].广州中医药大学学报,2016,33(1):12-16.
[16]肖定洪,黄智萍,张美荣,等.原发性胆汁反流性胃炎患者中医体质特点的病例对照研究[J].中国中西医结合消化杂志,2017,25(11):820-822,827.
[17]Chu X,Liu X,Qiu J,et al.Protection of Astragalus Polysaccharides and Codonopsis Pilosula Polysaccharides on Alveolar Macrophage Phagocytosis of Chronic Obstructive Pulmonary Disease Mice With PM2.5Inhalation[J].Chest,2016,149(4):A382-A382.
[18]Iguchi M,Kato J,Fukatsu K,et al.Serum pepsinogen levels can quantify the risk of development of metachronous gastric cancer after endoscopic resection[J].Inter J Cancer,2016,139(5):1150-1156.
[19]Tang CW,Feng WM,Bao Y,et al.Spleen-preserving Distal Pancreatectomy or Distal Pancreatectomy With Splenectomy?:Perioperative and Patient-reported Outcome Analysis[J].J Clin Gastroenterol,2014,48(7):e62.
[20]Matsukuma K,Gui D,Olson KA,et al.OsmoPrep-associated Gastritis:A Histopathologic Mimic of Iron Pill Gastritis and Mucosal Calcinosis[J].Am J Surg Pathol,2016,40(11):1550-1550.