近10年针灸治疗酒精性肝损伤的机制研究进展
|
摘要
对近10年针灸治疗酒精性肝损伤机制研究的相关文献进行分析。结果显示,针灸对酒精性肝损伤的作用机制主要体现在调节血管活性物质,增加肝血流量;加速氧化应激反应,促进乙醇代谢;调控免疫信号通路,促进内毒素排出;保护肝细胞膜,改善肝损伤状态等方面。认为针灸治疗酒精性肝损伤的机制在一定程度上是通过调节酒精性肝损伤的整体病理状态,并不局限于某一系统、某一水平或某一指标;从宏观指标如肠道菌群、能量代谢等方面探讨针灸的疗效机制可能也是一种方向。
This paper reviewed the research of therapeutic mechanism of acupuncture for alcoholic liver injury in recent ten years. The results showed that the therapeutic mechanism of acupuncture for alcoholic liver injury mainly manifested as regulating vasoactive substances to increase hepatic blood flow, accelerating oxidative stress reaction to promote the metabolism of ethanol, regulating the immune signaling pathways to promote the elimination of endotoxin,and protecting liver cell membrane for relieving hepatic injury. It is indicated that the therapeutic mechanism of acupuncture for alcoholic liver injury is focused on regulating the overall pathological state of alcoholic liver injury, not only limited to regulating one system, one level or one parameter. It is suggested that observation of macroscopic indexes such as intestinal flora and energy metabolism may be an approach to the therapeutic mechanism of acupuncture for alcoholic liver injury.
This paper reviewed the research of therapeutic mechanism of acupuncture for alcoholic liver injury in recent ten years. The results showed that the therapeutic mechanism of acupuncture for alcoholic liver injury mainly manifested as regulating vasoactive substances to increase hepatic blood flow, accelerating oxidative stress reaction to promote the metabolism of ethanol, regulating the immune signaling pathways to promote the elimination of endotoxin,and protecting liver cell membrane for relieving hepatic injury. It is indicated that the therapeutic mechanism of acupuncture for alcoholic liver injury is focused on regulating the overall pathological state of alcoholic liver injury, not only limited to regulating one system, one level or one parameter. It is suggested that observation of macroscopic indexes such as intestinal flora and energy metabolism may be an approach to the therapeutic mechanism of acupuncture for alcoholic liver injury.
引文
[1]Hagstr?m H.Alcohol,smoking and the liver disease patient[J].Best Pract Res Clin Gastroenterol,2017,31(5):537.
[2]Tranah T H,Vijay G K M,Ryan J M,et al.Dysfunctional neutrophil effector organelle mobilization and microbicidal protein release in alcohol-related cirrhosis[J].Am J Physiol-Gastr Liver physiol,2017,313(3):G203.
[3]Behari J,Sylvester K G.Role of the Wnt/β-Catenin pathway in the pathogenesis of alcoholic liver disease[J].Curr Mol Pharmacol,2017,10(3):186.
[4]Osna N A,Donohue T M.Alcoholic liver disease:pathogenesis and current management[J].Alcohol Res,2017,38(2):147.
[5]Shibamoto T,Tsutsumi M,Ohmukai C,et al.Ethanol predominantly constricts pre-sinusoids of isolated perfused livers of rat,guinea pig and mouse[J].Alcohol Alcohol,2011,46(2):117.
[6]Li Y,Xia W,Zhao F,et al.Prostaglandins in the pathogenesis of kidney diseases[J].Oncotarget,2018,9(41):26586.
[7]Yogi A,Callera G E,Hipólito U V,et al.Ethanol-induced vasoconstriction is mediated via redox-sensitive cyclo-oxygenasedependent mechanisms[J].Clin Sci(Lond),2010,118(11):657.
[8]李顺月,陈冰俊,张栋,等.电针对轻症酒精性肝损伤大鼠ET、TXA2和PGI2含量的影响[J].中国中医基础医学杂志,2012,18(7):766.
[9]白晓东.电针对急性酒精肝损伤血流灌注、肝脏代谢及血管调控物质的影响[D].北京:中国中医科学院,2014.
[10]郜风清,籍玉红,曹红格,等.通脉益智胶囊配合针灸治疗脑小血管病所致认知障碍的疗效及对TXA2、PGI2、ET及Hcy的影响[J].现代中西医结合杂志,2017,26(34):3841.
[11]Okata H,Hatta W,Iijima K,et al.Detection of acetaldehyde in the esophageal tissue among healthy male subjects after ethanol drinking and subsequent L-cysteine intake[J].Tohoku JExp Med,2018,244(4):317.
[12]Beier J I,McClain C J.Mechanisms and cell signaling in alcoholic liver disease[J].Biol Chem,2010,391(11):1294.
[13]Ceni E,Mello T,Galli A.Pathogenesis of alcoholic liver disease:role of oxidative metabolism[J].World J Gastroenterol,2014,20(47):17756.
[14]唐丽梅.电针对急性酒精性肝损伤小鼠肝血流灌注及氧化应激反应的影响研究[D].北京:中国中医科学院,2014.
[15]矫承媛.加皮葛根饮抗大鼠酒精性肝损伤与针刺协同增效作用的实验研究[D].沈阳:辽宁中医学院,2005.
[16]Chen Y,Wu Z,Yuan B,et al.MicroRNA-146a-5p attenuates irradiation-induced and LPS-induced hepatic stellate cell activation and hepatocyte apoptosis through inhibition of TLR4pathway[J].Cell Death Dis,2018,9(2):22.
[17]Lu Y,Xu J,Chen S,et al.Lipopolysaccharide promotes angiogenesis in mice model of HCC by stimulating hepatic stellate cell activation via TLR4 pathway[J].Acta Biochim Biophys Sin(Shanghai),2017,49(11):1029.
[18]Prestigiacomo V,Suter-Dick L.Nrf2 protects stellate cells from Smad-dependent cell activation[J].PLoS One,2018,13(7):e0201044.
[19]Sánchez-Valle V,Chávez-Tapia N C,Uribe M,et al.Role of oxidative stress and molecular changes in liver fibrosis:a review[J].Curr Med Chem,2012,19(28):4850.
[20]Clark C E,Nourse C C,Cooper H M.The tangled web of non-canonical Wnt signalling in neural migration[J].Neurosignals,2012,20(3):202.
[21]李瑞雪.穴位埋线对酒精性肝病大鼠的治疗作用[D].西宁:青海大学,2016.
[22]孙洁.电针结合人胚胎间充质干细胞移植对酒精性肝纤维化模型大鼠干预的研究[D].北京:北京中医药大学,2012.
[23]Arellanes-Robledo J,Reyes-Gordillo K,Ibrahim J,et al.Ethanol targets nucleoredoxin/dishevelled interactions and stimulates phosphatidylinositol 4-phosphate production in vivo and in vitro[J].Biochem Pharmacol,2018,156(8):135.
[24]王威,刘旭来,于红,等.针刺“足三里”穴对慢性酒精性肝损伤大鼠肝细胞膜的影响[J].中国中医药信息杂志,2006,13(9):32.
[25]Zeng T,Yu J,Tan L,et al.Noninvasive indices for monitoring disease course in Chinese patients with autoimmune hepatitis[J].Clin Chim Acta,2018,486:135.
[26]张铭,郭顺根,边璇,等.针刺穴位与非穴位筋膜对酒精性肝纤维化模型大鼠干预的比较研究[J].中华中医药杂志,2012,27(9):2313.
[27]刘文吉.“天灸”对大鼠肝纤维化的防治效应研究[D].北京:北京中医药大学,2015.
[28]Wang X M,Lu Y,Wu L Y,et al.Moxibustion inhibits interleukin-12 and tumor necrosis factor alpha and modulates intestinal flora in rat with ulcerative colitis[J].World JGastroenterol,2012,18(46):6819.
[29]李顺月,宋晓晶,王淑友,等.能量代谢仪系统在针灸干预急性酒精性肝损伤中的应用[J].世界科学技术-中医药现代化,2016,18(12):2159.
[2]Tranah T H,Vijay G K M,Ryan J M,et al.Dysfunctional neutrophil effector organelle mobilization and microbicidal protein release in alcohol-related cirrhosis[J].Am J Physiol-Gastr Liver physiol,2017,313(3):G203.
[3]Behari J,Sylvester K G.Role of the Wnt/β-Catenin pathway in the pathogenesis of alcoholic liver disease[J].Curr Mol Pharmacol,2017,10(3):186.
[4]Osna N A,Donohue T M.Alcoholic liver disease:pathogenesis and current management[J].Alcohol Res,2017,38(2):147.
[5]Shibamoto T,Tsutsumi M,Ohmukai C,et al.Ethanol predominantly constricts pre-sinusoids of isolated perfused livers of rat,guinea pig and mouse[J].Alcohol Alcohol,2011,46(2):117.
[6]Li Y,Xia W,Zhao F,et al.Prostaglandins in the pathogenesis of kidney diseases[J].Oncotarget,2018,9(41):26586.
[7]Yogi A,Callera G E,Hipólito U V,et al.Ethanol-induced vasoconstriction is mediated via redox-sensitive cyclo-oxygenasedependent mechanisms[J].Clin Sci(Lond),2010,118(11):657.
[8]李顺月,陈冰俊,张栋,等.电针对轻症酒精性肝损伤大鼠ET、TXA2和PGI2含量的影响[J].中国中医基础医学杂志,2012,18(7):766.
[9]白晓东.电针对急性酒精肝损伤血流灌注、肝脏代谢及血管调控物质的影响[D].北京:中国中医科学院,2014.
[10]郜风清,籍玉红,曹红格,等.通脉益智胶囊配合针灸治疗脑小血管病所致认知障碍的疗效及对TXA2、PGI2、ET及Hcy的影响[J].现代中西医结合杂志,2017,26(34):3841.
[11]Okata H,Hatta W,Iijima K,et al.Detection of acetaldehyde in the esophageal tissue among healthy male subjects after ethanol drinking and subsequent L-cysteine intake[J].Tohoku JExp Med,2018,244(4):317.
[12]Beier J I,McClain C J.Mechanisms and cell signaling in alcoholic liver disease[J].Biol Chem,2010,391(11):1294.
[13]Ceni E,Mello T,Galli A.Pathogenesis of alcoholic liver disease:role of oxidative metabolism[J].World J Gastroenterol,2014,20(47):17756.
[14]唐丽梅.电针对急性酒精性肝损伤小鼠肝血流灌注及氧化应激反应的影响研究[D].北京:中国中医科学院,2014.
[15]矫承媛.加皮葛根饮抗大鼠酒精性肝损伤与针刺协同增效作用的实验研究[D].沈阳:辽宁中医学院,2005.
[16]Chen Y,Wu Z,Yuan B,et al.MicroRNA-146a-5p attenuates irradiation-induced and LPS-induced hepatic stellate cell activation and hepatocyte apoptosis through inhibition of TLR4pathway[J].Cell Death Dis,2018,9(2):22.
[17]Lu Y,Xu J,Chen S,et al.Lipopolysaccharide promotes angiogenesis in mice model of HCC by stimulating hepatic stellate cell activation via TLR4 pathway[J].Acta Biochim Biophys Sin(Shanghai),2017,49(11):1029.
[18]Prestigiacomo V,Suter-Dick L.Nrf2 protects stellate cells from Smad-dependent cell activation[J].PLoS One,2018,13(7):e0201044.
[19]Sánchez-Valle V,Chávez-Tapia N C,Uribe M,et al.Role of oxidative stress and molecular changes in liver fibrosis:a review[J].Curr Med Chem,2012,19(28):4850.
[20]Clark C E,Nourse C C,Cooper H M.The tangled web of non-canonical Wnt signalling in neural migration[J].Neurosignals,2012,20(3):202.
[21]李瑞雪.穴位埋线对酒精性肝病大鼠的治疗作用[D].西宁:青海大学,2016.
[22]孙洁.电针结合人胚胎间充质干细胞移植对酒精性肝纤维化模型大鼠干预的研究[D].北京:北京中医药大学,2012.
[23]Arellanes-Robledo J,Reyes-Gordillo K,Ibrahim J,et al.Ethanol targets nucleoredoxin/dishevelled interactions and stimulates phosphatidylinositol 4-phosphate production in vivo and in vitro[J].Biochem Pharmacol,2018,156(8):135.
[24]王威,刘旭来,于红,等.针刺“足三里”穴对慢性酒精性肝损伤大鼠肝细胞膜的影响[J].中国中医药信息杂志,2006,13(9):32.
[25]Zeng T,Yu J,Tan L,et al.Noninvasive indices for monitoring disease course in Chinese patients with autoimmune hepatitis[J].Clin Chim Acta,2018,486:135.
[26]张铭,郭顺根,边璇,等.针刺穴位与非穴位筋膜对酒精性肝纤维化模型大鼠干预的比较研究[J].中华中医药杂志,2012,27(9):2313.
[27]刘文吉.“天灸”对大鼠肝纤维化的防治效应研究[D].北京:北京中医药大学,2015.
[28]Wang X M,Lu Y,Wu L Y,et al.Moxibustion inhibits interleukin-12 and tumor necrosis factor alpha and modulates intestinal flora in rat with ulcerative colitis[J].World JGastroenterol,2012,18(46):6819.
[29]李顺月,宋晓晶,王淑友,等.能量代谢仪系统在针灸干预急性酒精性肝损伤中的应用[J].世界科学技术-中医药现代化,2016,18(12):2159.