P62蛋白与疾病相关性的研究进展
摘要
P62可与许多信号转导因子互相作用,调节多种细胞功能。P62参与了炎症反应、代谢相关性疾病、年龄相关性黄斑变性、恶性肿瘤及自身免疫性疾病的发病,并发挥重要作用,但其中确切的关系仍需进一步研究探索。本文就此作一综述,旨在为上述疾病的治疗提供新思路。
引文
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[8]MOSCAT J,DIAZ-MECO M T.Feedback on fat:P62-mTORC1-autophagy connections[J].Cell,2011,147(4):724-727.
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[10]CANO M,WANG L,WAN J,et al.Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells[J].Free Radic Biol Med,2014,69(7):1-14.
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[12]朱书彤,赵越.PPARα在肝脏相关疾病中作用的研究进展[J].生命科学,2017,29(5):479-484.
[13]TAKAMURA A,KOMATSU M,HARA T,et al.Autophagy-deficient mice develop multiple liver tumors[J].Genes Dev,2011,25(8):795-800.
[14]顾澄宇.SQSTM1/P62在肝癌缺氧,营养缺乏微环境中的作用及机制研究[D].上海:复旦大学,2012.
[15]沈山.P62/SQSTM1:RA关节滑膜炎的可靠标记物[C].中华口腔医学会第四届颞下颌关节病学及牙合学专业委员会换届大会暨第十一次全国颞下颌关节病学及牙合学学术研讨会论文集,2014.
[16]KRAEMER D M,HANS-PETER T.Nuclear pore protein P62 autoantibodies in systemic lupus erythematosus[J].Open Rheumatol J,2010,4(1):24-27.
[17]GRANITO A,MURATORI P,QUARNETI C,et al.Antinuclear antibodies as ancillary markers in primary biliary cirrhosis[J].Expert Rev Mol Diagn,2012,12(1):65-74.
[18]SASAKI M,MIYAKOSHI M,SATO Y,et al.A possible involvement of P62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis[J].Liver Int,2011,32(3):487-499.
[2]SANZ L,DIAZ-MECO M T,NAKANO H,et al.The atypical PKC-interacting protein P62 channels NF-κB activation by the IL-1-TRAF6 pathway[J].EMBO Journal,2000,19(7):1576-1586.
[3]MOSCAT J,DIAZ-MECO M T.P62:a versatile multitasker takes on cancer[J].Trends Biochem Sci,2012,37(6):230-236.
[4]廖贵华,黄文峰.P62在喉癌Hep-2细胞化疗耐药中的作用[J].中国病理生理杂志,2017,33(6):1031-1037.
[5]PANKIV S,CLAUSEN T H,LAMARK T,et al.P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy[J].J Biol Chem,2007,282(33):24131-24145.
[6]PONPUAK M,DAVIS A S,ROBERTS E A,et al.Delivery of cytosolic components by autophagic adaptor protein P62 endows autophagosomes with unique antimicrobial properties[J].Immunity,2010,32(3):329-341.
[7]MATHEW R,KARP C M,BEAUDOIN B,et al.Autophagy suppresses tumorigenesis through elimination of P62[J].Cell,2009,137(6):1062-1075.
[8]MOSCAT J,DIAZ-MECO M T.Feedback on fat:P62-mTORC1-autophagy connections[J].Cell,2011,147(4):724-727.
[9]RODRIGUEZ A,DURAN A,SELLOUM M,et al.Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter P62[J].Cell Metab,2006,3(3):211-222.
[10]CANO M,WANG L,WAN J,et al.Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells[J].Free Radic Biol Med,2014,69(7):1-14.
[11]SONG C,MITTER S K,QI X,et al.Oxidative stress-mediated NF-κB phosphorylation up-regulates P62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy[J].PLoS One,2017,12(2):e0171940.
[12]朱书彤,赵越.PPARα在肝脏相关疾病中作用的研究进展[J].生命科学,2017,29(5):479-484.
[13]TAKAMURA A,KOMATSU M,HARA T,et al.Autophagy-deficient mice develop multiple liver tumors[J].Genes Dev,2011,25(8):795-800.
[14]顾澄宇.SQSTM1/P62在肝癌缺氧,营养缺乏微环境中的作用及机制研究[D].上海:复旦大学,2012.
[15]沈山.P62/SQSTM1:RA关节滑膜炎的可靠标记物[C].中华口腔医学会第四届颞下颌关节病学及牙合学专业委员会换届大会暨第十一次全国颞下颌关节病学及牙合学学术研讨会论文集,2014.
[16]KRAEMER D M,HANS-PETER T.Nuclear pore protein P62 autoantibodies in systemic lupus erythematosus[J].Open Rheumatol J,2010,4(1):24-27.
[17]GRANITO A,MURATORI P,QUARNETI C,et al.Antinuclear antibodies as ancillary markers in primary biliary cirrhosis[J].Expert Rev Mol Diagn,2012,12(1):65-74.
[18]SASAKI M,MIYAKOSHI M,SATO Y,et al.A possible involvement of P62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis[J].Liver Int,2011,32(3):487-499.