乙酰苯胺的合成方法
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摘要
乙酰苯胺是重要的化学试剂和常用的化工原料,被广泛用作香料、制药原料和化工中间体。随着合成技术的进步,乙酰苯胺的合成方法也在逐渐向高效、绿色环保的方向发展。查阅了近年来乙酰苯胺合成方面的文献资料,通过对不同合成方法的分析比较,阐述了目前乙酰苯胺新的合成方法与合成工艺,并对未来的发展方向提出展望。
Acetanilide is an important chemical reagent and commonly used as chemical raw material, pharmaceutical raw material and chemical intermediate. With the development of synthetic technology, high efficiency and green synthesis methods of acetanilide have also been gradually developed. In this paper, synthesis methods of acetanilide were summarized. These synthesis methods were compared; new synthesis methods were discussed as well as development trend of the synthesis methods in future.
Acetanilide is an important chemical reagent and commonly used as chemical raw material, pharmaceutical raw material and chemical intermediate. With the development of synthetic technology, high efficiency and green synthesis methods of acetanilide have also been gradually developed. In this paper, synthesis methods of acetanilide were summarized. These synthesis methods were compared; new synthesis methods were discussed as well as development trend of the synthesis methods in future.
引文
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[15]王桂艳,张瑞仁,王旭.微量、半微量法合成乙酰苯胺.黑龙江医药科学,2006,29(6):89.
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[19]伊茂聪,毛武涛,王建辉.乙酰苯胺合成新方法[J].化学与生物工程,2011,28(12):56-58.
[20]沈凤翠,任一鸣,张灵恩.盐酸硫胺催化合成乙酰苯胺的新工艺[J].光谱实验室,2012,29(5):2732-2735.
[21]沈凤翠,任一鸣,张强.碘催化合成乙酰苯胺[J].光谱实验室,2013,30(4):1614-1617.
[2]杨吉芳.乙酰苯胺制备的微型实验探讨[J].齐齐哈尔医学院报,2003,24(12):1396-1397.
[3]张力,李康兰,白林.乙酰苯胺的绿色化学研究[J].甘肃高师报,2010,15(5):16-18.
[4]罗一鸣,游力书,欧阳淑媛,等.乙酰苯胺的简易合成法[J].精细化工,1997,14(1):55-57.
[5]沈小雷,夏明芳,谭凤宜.乙酰苯胺的合成[J].精细石油化工进展,2002,3(8):49-50.
[6]袁晓燕.射频辐射合成乙酰苯胺的探索性研究[J].益阳师专学报,1998,15(6):54-57.
[7]Gedye R,Smith F,Westaway K,et al.The use of microwave ovens for rapid organic synthesis[J].tetrahedron Lett.,1986,27:279.
[8]FAN Xing-jun,YOU Jin-mao,TAN Gan-zu,et al.Progress in microwave organic reaction enhancement chemistry[J].Progress in Chemistry,1998,10(3):285.
[9]ZHANG Han-qi,JIN Qin-han.Microwave chemistry[J].University Chemistry,2001,16(1):32(Ch).
[10]张力,白林,李康兰,王永红.微波化学实验Ⅱ.乙酰苯胺的合成[J].甘肃高师学报,2006,11(5):86-87.
[11]周金梅,林敏,杨俐锋.微波法合成乙酰苯胺[J].厦门大学学报,2003,42(5):679-681.
[12]张承红,陈虹,郝世雄,何为.乙酰苯胺的微波合成研究[J].化工时刊,2006,20(10):35-36.
[13]陈虹,马燮,黄斌.微波合成乙酰苯胺的研究.四川化工,2007,10(1):9-11.
[14]范雪娥,王彦美,王建革,王建平.乙酰苯胺半微量合成的优化[J].洛阳师范学院学报,2000,19(5):49-50.
[15]王桂艳,张瑞仁,王旭.微量、半微量法合成乙酰苯胺.黑龙江医药科学,2006,29(6):89.
[16]Robert R M,et al,Modern Experimental Organic Chemistry[M].4th Ed,Saunders College Publishing,1985:478.
[17]张健,梁柏宏.乙酰苯胺合成工艺的改进[J].应用化工,2007,36(3):298-301.
[18]Moore J A,et.al,Experimental Methods in Organic Chemistry[M].3rd Ed,Saunders College Publishing,1982:35.
[19]伊茂聪,毛武涛,王建辉.乙酰苯胺合成新方法[J].化学与生物工程,2011,28(12):56-58.
[20]沈凤翠,任一鸣,张灵恩.盐酸硫胺催化合成乙酰苯胺的新工艺[J].光谱实验室,2012,29(5):2732-2735.
[21]沈凤翠,任一鸣,张强.碘催化合成乙酰苯胺[J].光谱实验室,2013,30(4):1614-1617.