野鸦椿属植物化学成分和药理活性研究进展
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摘要
野鸦椿属植物共有3种,中国有2种,分别为野鸦椿Euscaphis japonica和圆齿野鸦椿Euscaphis konishii,具有较高的药用价值,是民间常用的药用植物。目前,野鸦椿属植物中已发现的化学成分主要有三萜类、酚酸类、黄酮类、倍半萜类及其他类,其具有抗炎、抗肿瘤、抗肝纤维化、抑菌等药理活性。对野鸦椿属植物的化学成分及其药理活性进行综述,为其药用资源的开发和药效物质基础的研究提供参考。
There are three species of medicinal plants of Euscaphis, and two of them are species in China, including Euscaphis japonica and E. konishii, which are valuable traditional Chinese medicine, and are widely used in the folk. Until now, triterpenes, phenoic acids, flavonoids, sesquiterpenes and others components have been found in Euscaphis. Accumulating studies showed that Euscaphis possess the pharmacological activity of anti-inflammatory, anticancer, antiliver fibrosis and antibacteria. This article summarized the chemical and pharmacological research of Euscaphis, which would provide reference to its plant resources utilization and medicinal material basic research.
There are three species of medicinal plants of Euscaphis, and two of them are species in China, including Euscaphis japonica and E. konishii, which are valuable traditional Chinese medicine, and are widely used in the folk. Until now, triterpenes, phenoic acids, flavonoids, sesquiterpenes and others components have been found in Euscaphis. Accumulating studies showed that Euscaphis possess the pharmacological activity of anti-inflammatory, anticancer, antiliver fibrosis and antibacteria. This article summarized the chemical and pharmacological research of Euscaphis, which would provide reference to its plant resources utilization and medicinal material basic research.
引文
[1]吴德邻.广东植物志(第三卷)[M].广州:广东科技出版社,1995.
[2]方文培.四川植物志(第一卷)[M].四川:四川人民出版社,1981.
[3]萧德华,刘春海,谭电波.湖南药物志(第六卷)[M].长沙:湖南科学技术出版社,2004.
[4]刘文啟.野鸦椿鉴别研究[J].中国中药杂志,2007,32(3):261-263.
[5]赵秀贞,江英志.福建药物志(第一卷)[M].福州:福建科学技术出版社,1994.
[6]方文培.中国植物志(46卷)[M].北京:科学出版社,1981.
[7]肖平,李祥,陈伟建,等.中药药效物质基础研究思路与方法概述[J].时珍国医国药,2014,25(8):1935-1938.
[8]Cheng J J,Zhang L J,Cheng H L.Cytotoxic hexacyclic triterpene acids from Euscaphis japonica[J].J Nat Prod,2010,73(10):1655-1658.
[9]Li Y C,Tian K,Sun L J,et al.A new hexacyclic triterpene acid from the roots of Euscaphis japonica and its inhibitory activity on triglyceride accumulation[J].Fitoterapia,2016,doi:10.1016/j.fitote.2016.01.016.
[10]Zhang L J,Cheng J J,Liao C C,et al.Triterpene acids from Euscaphis japonica and assessment of their cytotoxic and anti-NO activities[J].Planta Med,2012,78(14):1584-1590.
[11]向德标,胡乔铭,谭洋,等.野鸦椿籽中三萜类化合物的分离与鉴定[J].中草药,2015,47(4):793-796.
[12]Takahashi K,Kawaguchi S,Nishimura K,et al.Studies on constituents of medicinal plants.XIII.constituents of the pericarps of the capsules of Euscaphis japonica Pax.(1)[J].Chem Pharm Bull,1974,22(3):650-653.
[13]Lee M K,Lee K Y,Jeon H Y.Antifibrotic activity of triterpenoids from the aerial parts of Euscaphis japonica on hepatic stellate cells[J].J Enzym Inhib Med Chem,2009,24(6):1276-1279.
[14]田珂,李燕慈,龙慧,等.野鸦椿根抑制肝脂堆积活性部位及其化学成分研究[J].中草药,2017,48(8):1519-1523.
[15]王爱民,刘智,王海军,等.UPLC测定鸡眼睛药材中鞣花酸类化合物的含量[J].中国中药杂志,2009,34(24):3235-3238.
[16]Maeda H,Matsuo Y,Tanaka T,et al.Euscaphinin,a new ellagitannin dimer from Euscaphis japonica(Thunb.)Kantiz[J].Chem Pharm Bull,2000,48(5):752-754.
[17]黄云,向德标,胡乔民,等.福建野鸦椿野鸦椿籽中的酚酸类化学成分[J].中草药,2014,45(18):2611-2613.
[18]Lee M K,Jeon H Y,Lee K Y,et al.Inhibitory constituents of Euscaphis japonica on lipopolysaccharide-induced nitric oxide production in BV2 microglia[J].Planta Med,2007,73(8):782-786.
[19]Takeda Y,Okada Y,Masuda T,et al.New megastigmane and tetraketide from the leaves of Euscaphis japonica[J].Chem Pharm Bull,2000,48(5):752-754.
[20]Takeda Y,Okada Y,Masuda T,et al.Euscapholide and its glucoside from leaves of Euscaphis japonica[J].Phytochemistry,1998,49(8):2565-2568.
[21]董玫,张秋霞,广田满.野鸦椿酯类化合物抗炎症活性与结构的研究[J].天然产物研究与开发,2004,16(4):290-293.
[22]Konish T,Otani T,Kiyosawa S,et al.Constituents of the capsules of Euscaphis Japonica(Thunb.)Kantiz[J].Chem Pharm Bull,1996,44(4):863-864.
[23]张天泰,姜威,王坚成,等.国家自然科学基金2010—2015年基于炎症相关研究的资助项目分析[J].中国药理学通报,2016,32(6):741-746.
[24]李先辉,李春艳,贾薇,等.野鸦椿提取物抗炎镇痛效应的研究[J].时珍国医国药,2009,20(8):2041-2042.
[25]董玫,广田满.野鸦椿的植物化学成分研究[J].天然产物的研究与开发,2002,14(4):34-37.
[26]左敏,倪志宇,许立,等.野鸦椿对Hala细胞的抗增殖作用及其机制的初步研究[J].癌变·畸变·突变,2008,20(5):350-353.
[27]谢玉宝,萧焕明,施梅姐,等.肝纤维化的中医药治疗进展[J].时珍国医国药,2016,27(23):703-706.
[28]高辉,钟飞,李春燕,等.野鸦椿水提取对大鼠抗肝纤维化的影响[J].吉首大学学报:自然科学版,2010,31(5):104-106.
[29]何玲,高辉,李春燕,等.野鸦椿对肝纤维化大鼠血清HA、LN及PIIIP的影响[J].山东医学高等专科学校学报,2010,32(6):411-413.
[30]陶文剑,韩燕.LXRs在脂质代谢中的调节机制[J].医学信息,2014,27(12):467-469.
[31]Kim K H,Choi S H,Lee T S,et al.Selective LXR alpha inhibitoryeffects observed in plant extracts of MEH184(Parthenocissua tricuspidata)and MEH185(Euscaphis japonica)[J].Biochem Bioph Res Commun,2006,349(2):513-518.
[32]李燕慈.野鸦椿根的化学成分及其抑制脂堆积活性研究[D].武汉:湖北大学,2017.
[33]罗李娜,向德标,胡乔铭,等.野鸦椿籽不同极性提取物抗菌作用研究[J].中成药,2014,36(10):2215-2217.
[2]方文培.四川植物志(第一卷)[M].四川:四川人民出版社,1981.
[3]萧德华,刘春海,谭电波.湖南药物志(第六卷)[M].长沙:湖南科学技术出版社,2004.
[4]刘文啟.野鸦椿鉴别研究[J].中国中药杂志,2007,32(3):261-263.
[5]赵秀贞,江英志.福建药物志(第一卷)[M].福州:福建科学技术出版社,1994.
[6]方文培.中国植物志(46卷)[M].北京:科学出版社,1981.
[7]肖平,李祥,陈伟建,等.中药药效物质基础研究思路与方法概述[J].时珍国医国药,2014,25(8):1935-1938.
[8]Cheng J J,Zhang L J,Cheng H L.Cytotoxic hexacyclic triterpene acids from Euscaphis japonica[J].J Nat Prod,2010,73(10):1655-1658.
[9]Li Y C,Tian K,Sun L J,et al.A new hexacyclic triterpene acid from the roots of Euscaphis japonica and its inhibitory activity on triglyceride accumulation[J].Fitoterapia,2016,doi:10.1016/j.fitote.2016.01.016.
[10]Zhang L J,Cheng J J,Liao C C,et al.Triterpene acids from Euscaphis japonica and assessment of their cytotoxic and anti-NO activities[J].Planta Med,2012,78(14):1584-1590.
[11]向德标,胡乔铭,谭洋,等.野鸦椿籽中三萜类化合物的分离与鉴定[J].中草药,2015,47(4):793-796.
[12]Takahashi K,Kawaguchi S,Nishimura K,et al.Studies on constituents of medicinal plants.XIII.constituents of the pericarps of the capsules of Euscaphis japonica Pax.(1)[J].Chem Pharm Bull,1974,22(3):650-653.
[13]Lee M K,Lee K Y,Jeon H Y.Antifibrotic activity of triterpenoids from the aerial parts of Euscaphis japonica on hepatic stellate cells[J].J Enzym Inhib Med Chem,2009,24(6):1276-1279.
[14]田珂,李燕慈,龙慧,等.野鸦椿根抑制肝脂堆积活性部位及其化学成分研究[J].中草药,2017,48(8):1519-1523.
[15]王爱民,刘智,王海军,等.UPLC测定鸡眼睛药材中鞣花酸类化合物的含量[J].中国中药杂志,2009,34(24):3235-3238.
[16]Maeda H,Matsuo Y,Tanaka T,et al.Euscaphinin,a new ellagitannin dimer from Euscaphis japonica(Thunb.)Kantiz[J].Chem Pharm Bull,2000,48(5):752-754.
[17]黄云,向德标,胡乔民,等.福建野鸦椿野鸦椿籽中的酚酸类化学成分[J].中草药,2014,45(18):2611-2613.
[18]Lee M K,Jeon H Y,Lee K Y,et al.Inhibitory constituents of Euscaphis japonica on lipopolysaccharide-induced nitric oxide production in BV2 microglia[J].Planta Med,2007,73(8):782-786.
[19]Takeda Y,Okada Y,Masuda T,et al.New megastigmane and tetraketide from the leaves of Euscaphis japonica[J].Chem Pharm Bull,2000,48(5):752-754.
[20]Takeda Y,Okada Y,Masuda T,et al.Euscapholide and its glucoside from leaves of Euscaphis japonica[J].Phytochemistry,1998,49(8):2565-2568.
[21]董玫,张秋霞,广田满.野鸦椿酯类化合物抗炎症活性与结构的研究[J].天然产物研究与开发,2004,16(4):290-293.
[22]Konish T,Otani T,Kiyosawa S,et al.Constituents of the capsules of Euscaphis Japonica(Thunb.)Kantiz[J].Chem Pharm Bull,1996,44(4):863-864.
[23]张天泰,姜威,王坚成,等.国家自然科学基金2010—2015年基于炎症相关研究的资助项目分析[J].中国药理学通报,2016,32(6):741-746.
[24]李先辉,李春艳,贾薇,等.野鸦椿提取物抗炎镇痛效应的研究[J].时珍国医国药,2009,20(8):2041-2042.
[25]董玫,广田满.野鸦椿的植物化学成分研究[J].天然产物的研究与开发,2002,14(4):34-37.
[26]左敏,倪志宇,许立,等.野鸦椿对Hala细胞的抗增殖作用及其机制的初步研究[J].癌变·畸变·突变,2008,20(5):350-353.
[27]谢玉宝,萧焕明,施梅姐,等.肝纤维化的中医药治疗进展[J].时珍国医国药,2016,27(23):703-706.
[28]高辉,钟飞,李春燕,等.野鸦椿水提取对大鼠抗肝纤维化的影响[J].吉首大学学报:自然科学版,2010,31(5):104-106.
[29]何玲,高辉,李春燕,等.野鸦椿对肝纤维化大鼠血清HA、LN及PIIIP的影响[J].山东医学高等专科学校学报,2010,32(6):411-413.
[30]陶文剑,韩燕.LXRs在脂质代谢中的调节机制[J].医学信息,2014,27(12):467-469.
[31]Kim K H,Choi S H,Lee T S,et al.Selective LXR alpha inhibitoryeffects observed in plant extracts of MEH184(Parthenocissua tricuspidata)and MEH185(Euscaphis japonica)[J].Biochem Bioph Res Commun,2006,349(2):513-518.
[32]李燕慈.野鸦椿根的化学成分及其抑制脂堆积活性研究[D].武汉:湖北大学,2017.
[33]罗李娜,向德标,胡乔铭,等.野鸦椿籽不同极性提取物抗菌作用研究[J].中成药,2014,36(10):2215-2217.