活络通脑片对脑卒中的预防作用研究(Ⅱ)
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摘要
目的:考察活络通脑片对脑卒中的预防作用。方法:建立大鼠双侧颈总动脉结扎再灌注损伤模型和栓线法致大鼠局灶性脑缺血-再灌注损伤模型,分别观察活络通脑片对这2种脑卒中动物模型的影响。结果:活络通脑片能显著减轻2种模型大鼠脑组织病理学损伤改变,提高模型大鼠脑组织/血清SOD活性并降低MDA含量;并能有效降低双侧颈总动脉结扎再灌注模型大鼠的脑含水量,有效改善大脑中动脉阻塞再灌注模型大鼠行为学指标及脑梗死范围。结论:预防性给予活络通脑片对脑卒中模型大鼠有一定的保护作用。
Objective:To study the prevention effect of Huoluotongnao tablet on stroke. Methods:Bilateral common carotid artery ligation and reperfusion injury model and reperfusion injury in focal cerebral ischemia-induced thrombosis line method rat model were used. Results:Huoluotongnao tablet could significantly reduce the pathological injury of rat brain tissue changes of these two models,and increase the activity of SOD and decrease the content of MDA in the brain tissue and plasma of rats. The brain water content of treatment groups were significantly reduced. The behavioral index and cerebral infarction range index were effectively improved in the middle cerebral artery occlusion reperfusion model rats. Conclusion:Huoluotongnao tablet has certain prevention effect on stroke.
Objective:To study the prevention effect of Huoluotongnao tablet on stroke. Methods:Bilateral common carotid artery ligation and reperfusion injury model and reperfusion injury in focal cerebral ischemia-induced thrombosis line method rat model were used. Results:Huoluotongnao tablet could significantly reduce the pathological injury of rat brain tissue changes of these two models,and increase the activity of SOD and decrease the content of MDA in the brain tissue and plasma of rats. The brain water content of treatment groups were significantly reduced. The behavioral index and cerebral infarction range index were effectively improved in the middle cerebral artery occlusion reperfusion model rats. Conclusion:Huoluotongnao tablet has certain prevention effect on stroke.
引文
[1]詹小容,马艺华,李承,等.活络通脑片对脑卒中的预防作用研究(Ⅰ)[J].中药材,2013,36(12):1983-1997.
[2]王维治.神经病学[M].第4版.北京:人民卫生出版社,2001.
[3]饶明俐.中国脑血管病防治指南[Z].北京:人民卫生出版社,2007.
[4]严丽荣,于焱.银杏叶提取物对老年心血管病患者MDA、NO含量和SOD、GSH-Px活性的影响[J].镇江医学院学报,2000,10(1):18-19.
[5]王玉华,李惠兰,李桂珍,等.银杏叶酒浸剂对血液流变学的改善作用[J].天津中医,2000,17(1):37-38.
[6]陈长勋,金若敏,李仪奎,等.银杏叶提取物改善小鼠记忆作用的研究[J].中国中药杂志,1991,16(11):681-683.
[7]沈明勤,陆泽安.银杏叶提取物对犬脑循环及后肢循环的作用[J].中药材,2000,23(12):764-766.
[8]孙占斌,吴莉.银杏叶制剂治疗短暂性脑缺血发作的22例观察[J].陕西中医,2008,29(6):672-673.
[9]李建军,张晓雷,王小姗,等.银杏叶提取物(EGb761)对鼠脑缺血半暗带神经细胞凋亡及超微结构的影响[J].蚌埠医学院学报,2008,33(4):400-403.
[10]杨荫文.银杏叶提取物对脑缺血再灌模型大鼠认知功能的影响[J].现代中医药,2008,28(3):64-66,78.
[11]刘新迎,周联,梁瑞燕,等.通过对3T3-L1细胞的作用探讨山楂叶总黄酮调脂机制[J].中华中医药学刊,2009,27(5):1066-1069.
[12]纪影实,张晓丹,李红,等.山楂叶总黄酮对脑缺血的保护作用[J].吉林大学学报(医学版),2005,31(6):879-883.
[13]昌喜涛,马金荣,尹尔丽.山楂叶总黄酮对大鼠脑缺血再灌注损伤的保护作用[J].中外健康文摘,2007,4(10):526-528.
[14]姜开余,顾振纶,阮长耿.WH505对实验性血栓形成的影响及其他作用机制[J].中成药,2000,22(11):782-785.
[15]李安国,贺石林.川芎嗪抗凝血酶诱导的单个核细胞——血小板聚集[J].中国药理学通报,1990,(5):311-313.
[16]陈懿,陈敏,刘吉勇,等.大鼠脑缺血再灌注后川芎嗪对其血浆TXB2及6-Keto-PGF1α含量的影响[J].血栓与止血学,2009,15(6):246-248.
[2]王维治.神经病学[M].第4版.北京:人民卫生出版社,2001.
[3]饶明俐.中国脑血管病防治指南[Z].北京:人民卫生出版社,2007.
[4]严丽荣,于焱.银杏叶提取物对老年心血管病患者MDA、NO含量和SOD、GSH-Px活性的影响[J].镇江医学院学报,2000,10(1):18-19.
[5]王玉华,李惠兰,李桂珍,等.银杏叶酒浸剂对血液流变学的改善作用[J].天津中医,2000,17(1):37-38.
[6]陈长勋,金若敏,李仪奎,等.银杏叶提取物改善小鼠记忆作用的研究[J].中国中药杂志,1991,16(11):681-683.
[7]沈明勤,陆泽安.银杏叶提取物对犬脑循环及后肢循环的作用[J].中药材,2000,23(12):764-766.
[8]孙占斌,吴莉.银杏叶制剂治疗短暂性脑缺血发作的22例观察[J].陕西中医,2008,29(6):672-673.
[9]李建军,张晓雷,王小姗,等.银杏叶提取物(EGb761)对鼠脑缺血半暗带神经细胞凋亡及超微结构的影响[J].蚌埠医学院学报,2008,33(4):400-403.
[10]杨荫文.银杏叶提取物对脑缺血再灌模型大鼠认知功能的影响[J].现代中医药,2008,28(3):64-66,78.
[11]刘新迎,周联,梁瑞燕,等.通过对3T3-L1细胞的作用探讨山楂叶总黄酮调脂机制[J].中华中医药学刊,2009,27(5):1066-1069.
[12]纪影实,张晓丹,李红,等.山楂叶总黄酮对脑缺血的保护作用[J].吉林大学学报(医学版),2005,31(6):879-883.
[13]昌喜涛,马金荣,尹尔丽.山楂叶总黄酮对大鼠脑缺血再灌注损伤的保护作用[J].中外健康文摘,2007,4(10):526-528.
[14]姜开余,顾振纶,阮长耿.WH505对实验性血栓形成的影响及其他作用机制[J].中成药,2000,22(11):782-785.
[15]李安国,贺石林.川芎嗪抗凝血酶诱导的单个核细胞——血小板聚集[J].中国药理学通报,1990,(5):311-313.
[16]陈懿,陈敏,刘吉勇,等.大鼠脑缺血再灌注后川芎嗪对其血浆TXB2及6-Keto-PGF1α含量的影响[J].血栓与止血学,2009,15(6):246-248.