精子DNA完整性对IVF-ET/ICSI累积活产率的影响
摘要
<正>精子DNA完整性,是反映精子核成熟度和DNA是否受到损伤的指标,其在辅助生殖领域中的临床意义,越来越受到人们的重视。过去,研究者用精子核DNA完整性来研究体外受精/卵细胞胞质内单精子注射(IVF/ICSI)妊娠以及活产的结局时,通常以新鲜移植周期的结局来分析两者是否存在相关性。随着胚胎冷冻-解冻技术的发展,越来越多的患
引文
[1] Mclernon DJ,Maheshwari A,Lee AJ,et al.Cumulative live birth rates after one or more complete cycles of IVF:A population-based study of linked cycle data from 178,898 women.Hum Reprod,2016,31(3):572-581
[2] Toftager M,Bogstad J,Lossl K,et al.Cumulative live birth rates after one ART cycle including all subsequent frozen-thaw cycles in 1050 women:Secondary outcome of an RCT comparing GnRH-antagonist and GnRH-agonist protocols.Hum Reprod,2017,32(3):556-567
[3] Maheshwari A,Mclernon D,Bhattacharya S.Cumulative live birth rate:Time for a consensus?Hum Reprod,2015,30(12):2703-2707
[4] Zhang HH,Xu PY,Wu J,et al.Dehydroepiandrosterone improves follicular fluid bone morphogenetic protein-15 and accumulated embryo score of infertility patients with diminished ovarian reserve undergoing in vitro fertilization:A randomized controlled trial.J Ovarian Res,2014,7:93
[5] Missmer SA,Pearson KR,Ryan LM,et al.Analysis of multiple-cycle data from couples undergoing in vitro fertilization:Methodologic issues and statistical approaches.Epidemiology,2011,22(4):497-504
[6] Ni W,Xiao S,Qiu X,et al.Effect of sperm DNA fragmentation on clinical outcome of frozen-thawed embryo transfer and on blastocyst formation.PLoS One,2014,9(4):e94956
[7] 吴春香,张婷,舒黎,等.每取卵周期的累积活产率在IVF/ICSI妊娠结局评估中的价值.中华妇产科杂志,2018,53(3) :160-166
[8] 潘荣,于玲,王涛,等.获卵数与IVF/ICSI累积活产率的相关性研究.生殖医学杂志,2018,27(02):117-122
[9] Mehta A,Bolyakov A,Schlegel PN,et al.Higher pregnancy rates using testicular sperm in men with severe oligospermia.Fertil Steril,2015,104(6):1382-1387
[10] Zini A.Use of testicular sperm for intracytoplasmic sperm injection in oligozoospermic couples with high levels of sperm deoxyribonucleic acid fragmentation.Fertil Steril,2015,104(6):1376-1377
[11] Simon L,Emery BR,Carrell DT.Review:Diagnosis and impact of sperm DNA alterations in assisted reproduction.Best Pract Res Clin Obstet Gynaecol,2017,44:38-56
[12] Esteves SC,Sanchez-Martin F,Sanchez-Martin P,et al.Comparison of reproductive outcome in oligozoospermic men with high sperm DNA fragmentation undergoing intracytoplasmic sperm injection with ejaculated and testicular sperm .Fertil Steril,2015,104(6):1398-1405
[13] Oleszczuk K,Giwercman A,Bungum M.Sperm chromatin structure assay in prediction of in vitro fertilization outcome.Andrology,2016,4(2):290-296
[14] Bach PV,Schlegel PN.Sperm DNA damage and its role in IVF and ICSI .Basic Clin Androl,2016,26:15-24
[15] Pregl BB,Kovacic B,Vlaisavljevic V.Are sperm DNA fragmentation,hyperactivation,and hyaluronan-binding ability predictive for fertilization and embryo development in in vitro fertilization and intracytoplasmic sperm injection?Fertil Steril,2013,99(5):1233-1241.
[16] 江伟杰,金帆,周黎明.优选后精子畸形指数、顶体异常率、DNA碎片指数预测IVF受精失败的价值.中华男科学杂志,2016,22(2):147-152
[17] Parmegiani L,Cognigni GE,Filicori M.Sperm selection:Effect on sperm DNA quality.Adv Exp Med Biol,2014,791:151-172
[18] 崔云,魏任雄,陈建伟,等.不育患者精子DNA链损伤类型的研究及临床意义.中华男科学杂志,2015,21(7):604-609
[19] Xu P,Cai X,Zhang W,et al.Flavonoids of Rosa roxburghii Tratt exhibit radioprotection and anti-apoptosis properties via the Bcl-2(Ca(2+))/Caspase-3/PARP-1 pathway.Apoptosis,2016,21(10):1125-1143
[20] 张国巍,蔡鸿财,商学军.泛素-蛋白酶体系统与精子DNA损伤修复的研究进展.中华男科学杂志,2016,22(9):834-837.
[21] Jin J,Pan C,Fei Q,et al.Effect of sperm DNA fragmentation on the clinical outcomes for in vitro fertilization and intracytoplasmic sperm injection in women with different ovarian reserves.Fertil Steril,2015,103(4):910-916
[2] Toftager M,Bogstad J,Lossl K,et al.Cumulative live birth rates after one ART cycle including all subsequent frozen-thaw cycles in 1050 women:Secondary outcome of an RCT comparing GnRH-antagonist and GnRH-agonist protocols.Hum Reprod,2017,32(3):556-567
[3] Maheshwari A,Mclernon D,Bhattacharya S.Cumulative live birth rate:Time for a consensus?Hum Reprod,2015,30(12):2703-2707
[4] Zhang HH,Xu PY,Wu J,et al.Dehydroepiandrosterone improves follicular fluid bone morphogenetic protein-15 and accumulated embryo score of infertility patients with diminished ovarian reserve undergoing in vitro fertilization:A randomized controlled trial.J Ovarian Res,2014,7:93
[5] Missmer SA,Pearson KR,Ryan LM,et al.Analysis of multiple-cycle data from couples undergoing in vitro fertilization:Methodologic issues and statistical approaches.Epidemiology,2011,22(4):497-504
[6] Ni W,Xiao S,Qiu X,et al.Effect of sperm DNA fragmentation on clinical outcome of frozen-thawed embryo transfer and on blastocyst formation.PLoS One,2014,9(4):e94956
[7] 吴春香,张婷,舒黎,等.每取卵周期的累积活产率在IVF/ICSI妊娠结局评估中的价值.中华妇产科杂志,2018,53(3) :160-166
[8] 潘荣,于玲,王涛,等.获卵数与IVF/ICSI累积活产率的相关性研究.生殖医学杂志,2018,27(02):117-122
[9] Mehta A,Bolyakov A,Schlegel PN,et al.Higher pregnancy rates using testicular sperm in men with severe oligospermia.Fertil Steril,2015,104(6):1382-1387
[10] Zini A.Use of testicular sperm for intracytoplasmic sperm injection in oligozoospermic couples with high levels of sperm deoxyribonucleic acid fragmentation.Fertil Steril,2015,104(6):1376-1377
[11] Simon L,Emery BR,Carrell DT.Review:Diagnosis and impact of sperm DNA alterations in assisted reproduction.Best Pract Res Clin Obstet Gynaecol,2017,44:38-56
[12] Esteves SC,Sanchez-Martin F,Sanchez-Martin P,et al.Comparison of reproductive outcome in oligozoospermic men with high sperm DNA fragmentation undergoing intracytoplasmic sperm injection with ejaculated and testicular sperm .Fertil Steril,2015,104(6):1398-1405
[13] Oleszczuk K,Giwercman A,Bungum M.Sperm chromatin structure assay in prediction of in vitro fertilization outcome.Andrology,2016,4(2):290-296
[14] Bach PV,Schlegel PN.Sperm DNA damage and its role in IVF and ICSI .Basic Clin Androl,2016,26:15-24
[15] Pregl BB,Kovacic B,Vlaisavljevic V.Are sperm DNA fragmentation,hyperactivation,and hyaluronan-binding ability predictive for fertilization and embryo development in in vitro fertilization and intracytoplasmic sperm injection?Fertil Steril,2013,99(5):1233-1241.
[16] 江伟杰,金帆,周黎明.优选后精子畸形指数、顶体异常率、DNA碎片指数预测IVF受精失败的价值.中华男科学杂志,2016,22(2):147-152
[17] Parmegiani L,Cognigni GE,Filicori M.Sperm selection:Effect on sperm DNA quality.Adv Exp Med Biol,2014,791:151-172
[18] 崔云,魏任雄,陈建伟,等.不育患者精子DNA链损伤类型的研究及临床意义.中华男科学杂志,2015,21(7):604-609
[19] Xu P,Cai X,Zhang W,et al.Flavonoids of Rosa roxburghii Tratt exhibit radioprotection and anti-apoptosis properties via the Bcl-2(Ca(2+))/Caspase-3/PARP-1 pathway.Apoptosis,2016,21(10):1125-1143
[20] 张国巍,蔡鸿财,商学军.泛素-蛋白酶体系统与精子DNA损伤修复的研究进展.中华男科学杂志,2016,22(9):834-837.
[21] Jin J,Pan C,Fei Q,et al.Effect of sperm DNA fragmentation on the clinical outcomes for in vitro fertilization and intracytoplasmic sperm injection in women with different ovarian reserves.Fertil Steril,2015,103(4):910-916