中药单体成分抗抑郁研究进展
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摘要
抑郁症以高患病率、高复发率、高致残率、高自杀率的特点使其成为严重影响人类生活质量和社会经济发展的公共卫生和社会问题。药物治疗是应对抑郁症的首要武器。中药在抑郁症治疗上取得了一定进展,应加强抗抑郁中药研究,从中药中筛选有效的活性成分,为临床新型抗抑郁药物研发提供理论依据。
Depression is a serious problem of public health and society,impacting the quality of human life and social economic development. It has the characteristics,such as high prevalence,high recurrence rate,high morbidity and high suicide rate. Drug therapy is the primary weapon to deal with depression. Traditional Chinese medicine( TCM) in the treatment of depression has made some progress. The research of anti- depression medicine should be strengthened and the effective active ingredients from traditional Chinese medicine screened. We should provide a theoretical basis for clinical research and development of new anti- depression drugs.
Depression is a serious problem of public health and society,impacting the quality of human life and social economic development. It has the characteristics,such as high prevalence,high recurrence rate,high morbidity and high suicide rate. Drug therapy is the primary weapon to deal with depression. Traditional Chinese medicine( TCM) in the treatment of depression has made some progress. The research of anti- depression medicine should be strengthened and the effective active ingredients from traditional Chinese medicine screened. We should provide a theoretical basis for clinical research and development of new anti- depression drugs.
引文
[1]Dennis CL,Dowswell T.Interventions(other than pharmacological,psychosocial or psychological)for treating antenatal depression[J].Cochrane Database Syst Rev,2013,7(7):6795-6802.
[2]军事医学科学院.军事医学科学院神经精神学研究进展[J].中国科学:生命科学,2011,41,(10):884-889.
[3]于文娟,朱丽萍.中医药治疗抑郁症的研究进展[J].精神医学杂志,2012,25(5):395-397.
[4]李那永.抑郁症中医证候要素及其分布特征研究[D].北京中医药大学,2013.
[5]Pathak L,Agrawal Y,Dhir A.Natural polyphenols in the management of major depression[J].Expert Opin Investig Drugs,2013,22(7):863-880.
[6]Lee SY,Lee SJ,Han C,et al.Oxidative/nitrosative stress and antidepressants:targets for novel antidepressants[J].Prog Neuropsychopharmacol Biol Psychiatry,2013,46(10):224-235.
[7]陈勤,叶海燕,陈逸青,等.红藻氨酸诱导PC12细胞凋亡及阿魏酸对神经元的保护作用[J].中国病理生理杂志,2013,29(7):1175-1180.
[8]张璐,王钱东,石华孟,等.阿魏酸对利血平诱导的疼痛抑郁症的影响[J].药学学报,2013,48(1):32-37.
[9]廖铭能,王艳平,张永平.阿魏酸钠的神经保护和神经发生增强作用[J].中国细胞生物学学报,2010,32(6):840-849.
[10]廖铭能,于立坚,张永平,等.阿魏酸钠诱导分化的PC12细胞裂解液的无细胞滤液的抗抑郁样效果[J].中国细胞生物学学报,2011,33(6):608-621.
[11]Xu Y,Zhang L,Shao T,et al.Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpinetreated mice:behavioral and neurobiological analyses[J].Metab Brain Dis,2013,28(4):571-83.
[12]Yabe T,Hirahara H,Harada N,et al.Ferulic acid induces neural progenitor cell proliferation in vitro and in vivo[J].Neuroscience,2010,165(2):515-24.
[13]Zhang H,Liu B,Wu J,Xu C,et al.Icariin inhibits corticosterone-induced apoptosis in hypothalamic neurons via the PI3-K/Akt signaling pathway[J].Mol Med Rep,2012,6(5):967-972.
[14]He XL,Zhou WQ,Bi MG,et al.Neuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons[J].Brain Res,2010,1334(1):73-83.
[15]Wu X,Wu J,Xia S,et al.Icaritin opposes the development of social aversion after defeat stress via increases of GR mR NA and BDNF mR NA in mice[J].Behav Brain Res,2013,256(11):602-608.
[16]Pan Y,Hong Y,Zhang QY,et al.Impaired hypothalamic insulin signaling in CUMS rats:restored by icariin and fluoxetine through inhibiting CRF system.Psychoneuroendocrinology[J].2013,38(1):122-134.
[17]石翠格,李慧,王丽丽,等.淫羊藿苷抗抑郁及对皮质酮致PC12细胞损伤的保护作用研究[J].中国药物应用与监测,2013,10(5):268-270.
[18]Pan Y,Zhang WY,Xia X,et al.Effects of icariin on hypothalamic-pituitary-adrenal axis action and cytokine levels in stressed Sprague-Dawley rats[J].Biol Pharm Bull,2006,29(12):2399-2403.
[19]龚其海,杨丹莉,石京山,等.淫羊蕾普的神经药理作用及分子机制研究进展[J].中国新药与临床杂志,2011,30(7):481-484.
[20]陈洋,黄建华,宁友,等.淫羊藿苷药理作用的分子机制研究进展[J].中西医结合学报,2011,9(11):1179-1184.
[21]曹瑞.α-synuclein和tau相互作用参与锰诱导的神经毒性机制及染料木素的保护作用[D].第四军医大学,2013.
[22]Wang H J,Murphy PA.Isoflavone content in commercial soybean foods[J].J Agric Food Chem,1994,42(8):1666-1673.
[23]王海挺.染料木素抗抑郁作用及其可能机制的研究[D].兰州:兰州大学,2008.
[24]罗思婧,黄庆,任冬冬,等.染料木素的神经保护作用及其机制的研究进展[J].广东药学院学报,2011,27(1):94-98.
[25]朱建华,郭开华,徐杰.染料木素对去卵巢大鼠学习一记忆能力的作用[J].中国临床康医学,2004,8(4):2-5.
[26]朱建华,郭开华,徐杰.染料木素对去卵巢大鼠脑突触体[Ca2+]i及膜流动性的影响[J].解剖学报,2005,36(2):131-134.
[27]MakhnovskiǐDA,Murzina GB,Tret'iakova MS,et al.The role of serine/threonine and tyrosine protein kinases in the depression of cholinosensitivity in Helix lucorum neurons in the cellular correlate of habituation[J].Zh Vyssh Nerv Deiat Im I P Pavlova,2011,61(4):459-475.
[28]殷复健.脱氢表雄酮与染料木素对老年大鼠抗氧化及脂代谢的调节作用[D].南京:南京农业大学,2012.
[29]王超.染料木素对Aβ25-35诱导大鼠胚胎海马神经元凋亡的神经保护作用[D].西安:第四军医大学,2009.
[30]Atteritano M,Mazzaferro S,Bitto A,et al.Genistein effects on quality of life and depression symptoms in osteopenic postmenopausal women:a 2-year randomized,double-blind,controlled study[J].Osteoporos Int,2014,25(3):1123-1129.
[31]Kageyama A,Sakakibara H,Zhou W,et al.Genistein regulated serotonergic activity in the hippocampus of ovariectomized rats under forced swimming stress[J].Biosci Biotechnol Biochem,2010,74(10):2005-2010.
[32]Singh IP,Mahajan S.Berberine and its derivatives:a patent review(2009-2012)[J].Expert Opin Ther Pat,2013,23(2):215-231.
[33]王丽萍,宋金春.小檗碱的药理学研究进展[J].中国药房,2013,24(43):4111-4114.
[34]刘为涛.小檗碱衍生物的制备及其神经营养活性研究[D].杨凌:西北农业大学,2008.
[35]Arora V,Chopra K.Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway:underpinning the correlation between nociceptive and depressive behaviour in a rodent model[J].J Affect Disord,2013,151(3):1041-1052.
[36]Lee B,Sur B,Yeom M,et al.Effect of berberine on depression-and anxiety-like behaviors and activation of the noradrenergic system induced by development of morphine dependence in rats[J].Korean J Physiol Pharmacol,2012,16(6):379-386.
[37]Kulkarni SK,Dhir A.On the mechanism of antidepressant-like action of berberine chloride[J].Eur J Pharmacol,2008,589(1-3):163-172.
[38]Kulkarni SK,Dhir A.Berberine:a plant alkaloid with therapeutic potential for central nervous system disorders[J].Phytother Res,2010,24(3):317-324.
[39]Wang N,Zhang Y,Wu L,et al.Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition[J].Neuropharmacology,2014,79(4):282-289.
[40]黎荣,徐灵源,梁韬,等.葛根素对6-羟多巴胺致帕金森病模型大鼠黑质组织神经细胞的保护作用[J].中国实验方剂学杂志,2013,19(2):247-250.
[41]王海岭,师天元.葛根异黄酮抗抑郁作用的实验研究[J].中国实验方剂学杂志,2012,18(2):268-271.
[42]孙颖,黄明亮,王华.白藜芦醇抗氧化性及安全性的研究进展[J].食品工业,2013,34(4):177-180.
[43]何丽莉,孙桂芝.虎杖及其提取物抗肝癌研究进展[J].辽宁中医药大学学报,2014,16(1):168-170.
[44]曹烨,关新强,徐志懿,等.白藜芦醇对心血管保护作用的研究进展[J].医学综述,2013,19(23):4235-4237.
[45]Li SY,Wang XB,Kong LY.Design,synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease[J].Eur J Med Chem,2013,4(71):36-45.
[46]Kumar A,Negi G,Sharma SS.Neuroprotection by resveratrol in diabetic neuropathy:concepts&mechanisms[J].Curr Med Chem,2013,20(36):4640-4645.
[47]Pathak L,Agrawal Y,Dhir A.Natural polyphenols in the management of major depression[J].Expert Opin Investig Drugs,2013,22(7):863-880.
[48]陈纯白,都霞,赵乐萍,等.白藜芦醇拮抗围绝经期抑郁模型小鼠的行为异常及机制研究[C]//中国药学会、烟台市人民政府.2011年中国药学大会暨第11届中国药师周论文集,中国药学会、烟台市人民政府,2011:7.
[49]Liu D,Xie K,Yang X,et al.Resveratrol reverses the effects of chronic unpredictable mild stress on behavior,serum corticosterone levels and BDNF expression in rats[J].Behav Brain Res,2014,4:S0166-4328.
[50]Bharat B Aqqarwal,Kuzhuvelil B Harikumar.Potentialtherapeutic effect of curucmin,the anti-inflammatory agent,against neurodegenerative,cardiovascular,pulmonary,metabolic,autoimmune and neoplastic diseases[J].Int J Biochem Cell Biol,2009,41(1):40-59.
[51]Pathak L,Agrawal Y,Dhir A.Natural polyphenols in the management of major depression[J].Expert Opin Investig Drugs,2013,22(7):863-880.
[52]Xu Ying,Ku Bao-shan,Yao Hai-yan,et al.Antidepression effect of curcumin in mice[J].中国临床康复杂志,2005,9(44):162-164.
[53]李学军.姜黄素-一个多靶点治疗药物的抗抑郁作用及其机制[C].第十一届全国中药药理学术大会论文摘要,2010:2.
[54]Brietzke E,Mansur RB,Zugman A,et al.Is there a role for curcumin in the treatment of bipolar disorder[J].Med Hypotheses,2013,80(5):606-612.
[55]Mohit Kumar Bhutani,Mahendra Bishnoi,Shrinivas K Kulkarni.Antidepressant like effects of curcumin and its、combination with piperine in unpredictable chronic stressinduced、behavioral,biochemical and neurochemical changes[J].Pharmacol Biochem Behav,2009,92(1):39-4362.
[56]马行,徐英,姚海燕,等.姜黄素对慢性应激大鼠不同脑区促肾上腺皮质激素释放因子表达的影响[J].中国药理学与毒理学杂志,2006,20(6):468-472.
[57]陈亮,吕平,潘建春,等.姜黄素对慢性应激大鼠肾上腺、血清ACTH和免疫功能的影响[J].2008,1(38):22-24.
[2]军事医学科学院.军事医学科学院神经精神学研究进展[J].中国科学:生命科学,2011,41,(10):884-889.
[3]于文娟,朱丽萍.中医药治疗抑郁症的研究进展[J].精神医学杂志,2012,25(5):395-397.
[4]李那永.抑郁症中医证候要素及其分布特征研究[D].北京中医药大学,2013.
[5]Pathak L,Agrawal Y,Dhir A.Natural polyphenols in the management of major depression[J].Expert Opin Investig Drugs,2013,22(7):863-880.
[6]Lee SY,Lee SJ,Han C,et al.Oxidative/nitrosative stress and antidepressants:targets for novel antidepressants[J].Prog Neuropsychopharmacol Biol Psychiatry,2013,46(10):224-235.
[7]陈勤,叶海燕,陈逸青,等.红藻氨酸诱导PC12细胞凋亡及阿魏酸对神经元的保护作用[J].中国病理生理杂志,2013,29(7):1175-1180.
[8]张璐,王钱东,石华孟,等.阿魏酸对利血平诱导的疼痛抑郁症的影响[J].药学学报,2013,48(1):32-37.
[9]廖铭能,王艳平,张永平.阿魏酸钠的神经保护和神经发生增强作用[J].中国细胞生物学学报,2010,32(6):840-849.
[10]廖铭能,于立坚,张永平,等.阿魏酸钠诱导分化的PC12细胞裂解液的无细胞滤液的抗抑郁样效果[J].中国细胞生物学学报,2011,33(6):608-621.
[11]Xu Y,Zhang L,Shao T,et al.Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpinetreated mice:behavioral and neurobiological analyses[J].Metab Brain Dis,2013,28(4):571-83.
[12]Yabe T,Hirahara H,Harada N,et al.Ferulic acid induces neural progenitor cell proliferation in vitro and in vivo[J].Neuroscience,2010,165(2):515-24.
[13]Zhang H,Liu B,Wu J,Xu C,et al.Icariin inhibits corticosterone-induced apoptosis in hypothalamic neurons via the PI3-K/Akt signaling pathway[J].Mol Med Rep,2012,6(5):967-972.
[14]He XL,Zhou WQ,Bi MG,et al.Neuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons[J].Brain Res,2010,1334(1):73-83.
[15]Wu X,Wu J,Xia S,et al.Icaritin opposes the development of social aversion after defeat stress via increases of GR mR NA and BDNF mR NA in mice[J].Behav Brain Res,2013,256(11):602-608.
[16]Pan Y,Hong Y,Zhang QY,et al.Impaired hypothalamic insulin signaling in CUMS rats:restored by icariin and fluoxetine through inhibiting CRF system.Psychoneuroendocrinology[J].2013,38(1):122-134.
[17]石翠格,李慧,王丽丽,等.淫羊藿苷抗抑郁及对皮质酮致PC12细胞损伤的保护作用研究[J].中国药物应用与监测,2013,10(5):268-270.
[18]Pan Y,Zhang WY,Xia X,et al.Effects of icariin on hypothalamic-pituitary-adrenal axis action and cytokine levels in stressed Sprague-Dawley rats[J].Biol Pharm Bull,2006,29(12):2399-2403.
[19]龚其海,杨丹莉,石京山,等.淫羊蕾普的神经药理作用及分子机制研究进展[J].中国新药与临床杂志,2011,30(7):481-484.
[20]陈洋,黄建华,宁友,等.淫羊藿苷药理作用的分子机制研究进展[J].中西医结合学报,2011,9(11):1179-1184.
[21]曹瑞.α-synuclein和tau相互作用参与锰诱导的神经毒性机制及染料木素的保护作用[D].第四军医大学,2013.
[22]Wang H J,Murphy PA.Isoflavone content in commercial soybean foods[J].J Agric Food Chem,1994,42(8):1666-1673.
[23]王海挺.染料木素抗抑郁作用及其可能机制的研究[D].兰州:兰州大学,2008.
[24]罗思婧,黄庆,任冬冬,等.染料木素的神经保护作用及其机制的研究进展[J].广东药学院学报,2011,27(1):94-98.
[25]朱建华,郭开华,徐杰.染料木素对去卵巢大鼠学习一记忆能力的作用[J].中国临床康医学,2004,8(4):2-5.
[26]朱建华,郭开华,徐杰.染料木素对去卵巢大鼠脑突触体[Ca2+]i及膜流动性的影响[J].解剖学报,2005,36(2):131-134.
[27]MakhnovskiǐDA,Murzina GB,Tret'iakova MS,et al.The role of serine/threonine and tyrosine protein kinases in the depression of cholinosensitivity in Helix lucorum neurons in the cellular correlate of habituation[J].Zh Vyssh Nerv Deiat Im I P Pavlova,2011,61(4):459-475.
[28]殷复健.脱氢表雄酮与染料木素对老年大鼠抗氧化及脂代谢的调节作用[D].南京:南京农业大学,2012.
[29]王超.染料木素对Aβ25-35诱导大鼠胚胎海马神经元凋亡的神经保护作用[D].西安:第四军医大学,2009.
[30]Atteritano M,Mazzaferro S,Bitto A,et al.Genistein effects on quality of life and depression symptoms in osteopenic postmenopausal women:a 2-year randomized,double-blind,controlled study[J].Osteoporos Int,2014,25(3):1123-1129.
[31]Kageyama A,Sakakibara H,Zhou W,et al.Genistein regulated serotonergic activity in the hippocampus of ovariectomized rats under forced swimming stress[J].Biosci Biotechnol Biochem,2010,74(10):2005-2010.
[32]Singh IP,Mahajan S.Berberine and its derivatives:a patent review(2009-2012)[J].Expert Opin Ther Pat,2013,23(2):215-231.
[33]王丽萍,宋金春.小檗碱的药理学研究进展[J].中国药房,2013,24(43):4111-4114.
[34]刘为涛.小檗碱衍生物的制备及其神经营养活性研究[D].杨凌:西北农业大学,2008.
[35]Arora V,Chopra K.Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway:underpinning the correlation between nociceptive and depressive behaviour in a rodent model[J].J Affect Disord,2013,151(3):1041-1052.
[36]Lee B,Sur B,Yeom M,et al.Effect of berberine on depression-and anxiety-like behaviors and activation of the noradrenergic system induced by development of morphine dependence in rats[J].Korean J Physiol Pharmacol,2012,16(6):379-386.
[37]Kulkarni SK,Dhir A.On the mechanism of antidepressant-like action of berberine chloride[J].Eur J Pharmacol,2008,589(1-3):163-172.
[38]Kulkarni SK,Dhir A.Berberine:a plant alkaloid with therapeutic potential for central nervous system disorders[J].Phytother Res,2010,24(3):317-324.
[39]Wang N,Zhang Y,Wu L,et al.Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition[J].Neuropharmacology,2014,79(4):282-289.
[40]黎荣,徐灵源,梁韬,等.葛根素对6-羟多巴胺致帕金森病模型大鼠黑质组织神经细胞的保护作用[J].中国实验方剂学杂志,2013,19(2):247-250.
[41]王海岭,师天元.葛根异黄酮抗抑郁作用的实验研究[J].中国实验方剂学杂志,2012,18(2):268-271.
[42]孙颖,黄明亮,王华.白藜芦醇抗氧化性及安全性的研究进展[J].食品工业,2013,34(4):177-180.
[43]何丽莉,孙桂芝.虎杖及其提取物抗肝癌研究进展[J].辽宁中医药大学学报,2014,16(1):168-170.
[44]曹烨,关新强,徐志懿,等.白藜芦醇对心血管保护作用的研究进展[J].医学综述,2013,19(23):4235-4237.
[45]Li SY,Wang XB,Kong LY.Design,synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease[J].Eur J Med Chem,2013,4(71):36-45.
[46]Kumar A,Negi G,Sharma SS.Neuroprotection by resveratrol in diabetic neuropathy:concepts&mechanisms[J].Curr Med Chem,2013,20(36):4640-4645.
[47]Pathak L,Agrawal Y,Dhir A.Natural polyphenols in the management of major depression[J].Expert Opin Investig Drugs,2013,22(7):863-880.
[48]陈纯白,都霞,赵乐萍,等.白藜芦醇拮抗围绝经期抑郁模型小鼠的行为异常及机制研究[C]//中国药学会、烟台市人民政府.2011年中国药学大会暨第11届中国药师周论文集,中国药学会、烟台市人民政府,2011:7.
[49]Liu D,Xie K,Yang X,et al.Resveratrol reverses the effects of chronic unpredictable mild stress on behavior,serum corticosterone levels and BDNF expression in rats[J].Behav Brain Res,2014,4:S0166-4328.
[50]Bharat B Aqqarwal,Kuzhuvelil B Harikumar.Potentialtherapeutic effect of curucmin,the anti-inflammatory agent,against neurodegenerative,cardiovascular,pulmonary,metabolic,autoimmune and neoplastic diseases[J].Int J Biochem Cell Biol,2009,41(1):40-59.
[51]Pathak L,Agrawal Y,Dhir A.Natural polyphenols in the management of major depression[J].Expert Opin Investig Drugs,2013,22(7):863-880.
[52]Xu Ying,Ku Bao-shan,Yao Hai-yan,et al.Antidepression effect of curcumin in mice[J].中国临床康复杂志,2005,9(44):162-164.
[53]李学军.姜黄素-一个多靶点治疗药物的抗抑郁作用及其机制[C].第十一届全国中药药理学术大会论文摘要,2010:2.
[54]Brietzke E,Mansur RB,Zugman A,et al.Is there a role for curcumin in the treatment of bipolar disorder[J].Med Hypotheses,2013,80(5):606-612.
[55]Mohit Kumar Bhutani,Mahendra Bishnoi,Shrinivas K Kulkarni.Antidepressant like effects of curcumin and its、combination with piperine in unpredictable chronic stressinduced、behavioral,biochemical and neurochemical changes[J].Pharmacol Biochem Behav,2009,92(1):39-4362.
[56]马行,徐英,姚海燕,等.姜黄素对慢性应激大鼠不同脑区促肾上腺皮质激素释放因子表达的影响[J].中国药理学与毒理学杂志,2006,20(6):468-472.
[57]陈亮,吕平,潘建春,等.姜黄素对慢性应激大鼠肾上腺、血清ACTH和免疫功能的影响[J].2008,1(38):22-24.