73例寻常型天疱疮患者预后分析
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摘要
目的:分析该院经治的寻常型天疱疮(PV)患者治愈用时及其影响因素。方法:回顾性分析该科2002年1月—2013年12月住院确诊且随访资料完整的73例PV患者,采用Kaplan-Meier生存曲线法分析患者治愈用时,Cox比例风险模型分析影响疾病治愈用时的独立危险因素。结果:60个月内获临床治愈的患者占61.9%,84个月内获完全治愈的患者占73.6%。Kaplan-Meier生存曲线法分析提示:按发病年龄、病情严重程度及依从性分组,组间完全治愈用时及临床治愈用时差异具有统计学意义。Cox比例风险模型分析提示:依从性是影响完全治愈用时及临床治愈用时的独立危险因素。结论:影响PV完全治愈及临床治愈的独立危险因素是患者依从性。
Objective: To analyze the cure times for pemphigus vulgaris(PV and its influential factors). Methods: A retrospective analysis was conducted in 73 PV patients who were treated and followed up in our clinic from January 2002 to December2013. Kaplan-Meier analysis was used to generate standard survival curves for cure times. Survival analysis with the Cox regression model was used to assess the influential factors of cure times. Results: The cure rates at 60 and 84 months were 61.9% and73.6%, respectively. Kaplan-Meier analysis showed that cure times were associated with onset age of PV, disease severity and patients' compliance. Analysis with Cox regression model showed that patient compliance was the independent factor for cure times.Conclusion: Patient compliance was the independent risk factor for cure times.
Objective: To analyze the cure times for pemphigus vulgaris(PV and its influential factors). Methods: A retrospective analysis was conducted in 73 PV patients who were treated and followed up in our clinic from January 2002 to December2013. Kaplan-Meier analysis was used to generate standard survival curves for cure times. Survival analysis with the Cox regression model was used to assess the influential factors of cure times. Results: The cure rates at 60 and 84 months were 61.9% and73.6%, respectively. Kaplan-Meier analysis showed that cure times were associated with onset age of PV, disease severity and patients' compliance. Analysis with Cox regression model showed that patient compliance was the independent factor for cure times.Conclusion: Patient compliance was the independent risk factor for cure times.
引文
[1] Saha M, Bhogal B, Black MM, et al. Prognostic factors in pemphigus vulgaris and pemphigus foliaceus[J]. Br J Dermatol, 2014,170(1):116-122.
[2] Svecova D. Pemphigus valgaris:a clinical study of 44 cases over a 20-years period[J]. Int J Dermatol, 2015, 54(10):1138-1144.
[3] Herbst A, Bystryn JC. Patterns of remission in pemphigus valgaris[J]. J Am Acad Dermatol, 2000, 42(3):422-427.
[4]王明悦,高昱,彭洋,等.糖皮质激素治愈寻常型天疱疮患者临床分析[J].临床皮肤科杂志, 2015, 44(11):679-681.
[5] Cholera M, Chainani-Wu N. Management of pemphigus vulgaris[J]. Adv Ther, 2016, 33(6):910-958.
[6] Mignogan MD, Fortuna G, Leuci S, et al. Oropharyngeal pemphigus vulgaris and clinical remission:a long-term, longitudinal study[J]. Am J Clin Dermatol, 2010, 11(2):137-145.
[7] Savin JA. Some factors affecting prognosis in pemphigus vulgaris and pemphigoid[J]. Br J Dermatol, 1981, 104(4):415-420.
[8] Bai YX, Zhang LM, Xiao T, et al. A 6-year treatment experience for pemphigus:retrospective study of 69 Chinese patients[J]. Dermatol Ther, 2016, 29(2):84-87.
[9] Valikhani M, Kavusi S, Chams-Davatchi C, et al. Impact of smoking on pemphigus vulgaris[J]. Int J Dermatol, 2008, 47(6):567-570.
[2] Svecova D. Pemphigus valgaris:a clinical study of 44 cases over a 20-years period[J]. Int J Dermatol, 2015, 54(10):1138-1144.
[3] Herbst A, Bystryn JC. Patterns of remission in pemphigus valgaris[J]. J Am Acad Dermatol, 2000, 42(3):422-427.
[4]王明悦,高昱,彭洋,等.糖皮质激素治愈寻常型天疱疮患者临床分析[J].临床皮肤科杂志, 2015, 44(11):679-681.
[5] Cholera M, Chainani-Wu N. Management of pemphigus vulgaris[J]. Adv Ther, 2016, 33(6):910-958.
[6] Mignogan MD, Fortuna G, Leuci S, et al. Oropharyngeal pemphigus vulgaris and clinical remission:a long-term, longitudinal study[J]. Am J Clin Dermatol, 2010, 11(2):137-145.
[7] Savin JA. Some factors affecting prognosis in pemphigus vulgaris and pemphigoid[J]. Br J Dermatol, 1981, 104(4):415-420.
[8] Bai YX, Zhang LM, Xiao T, et al. A 6-year treatment experience for pemphigus:retrospective study of 69 Chinese patients[J]. Dermatol Ther, 2016, 29(2):84-87.
[9] Valikhani M, Kavusi S, Chams-Davatchi C, et al. Impact of smoking on pemphigus vulgaris[J]. Int J Dermatol, 2008, 47(6):567-570.