氯吡格雷联合阿司匹林治疗急性心肌梗死的临床效果
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摘要
目的:分析氯吡格雷联合阿司匹林治疗急性心肌梗死的临床效果。方法:选择在我院收治的100例急性心肌梗死患者,分为氯吡格雷组与联合治疗组(氯吡格雷联合阿司匹林),各50例。两组均在常规药物治疗基础上采用上述不同治疗方案。疗程4周,比较两组患者的治疗总有效率、血小板聚集率、冠状动脉再通时间、凝血酶原时间、左心室射血分数以及住院期间心血管事件发生率等指标。结果:联合治疗组临床治疗总有效率明显高于氯吡格雷组(96.00%比80.00%,P=0.014);治疗后,与氯吡格雷组比较,联合治疗组患者的血小板聚集率[(47.63±7.83)%比(38.45±8.55)%]及心血管事件发生率(24.00%比4.00%)显著降低,冠状动脉再通时间[(45.44±4.42)比(41.93±5.85)]显著缩短,左心室射血分数[(48.56±5.79)%比(55.51±6.44)%]显著提高(P均<0.01)。结论:氯吡格雷联合阿司匹林治疗急性心肌梗死的临床效果显著。
Objective:To comprehensively analyze therapeutic effect of clopidogrel combined aspirin on acute myocardial infarction(AMI).Methods:A total of 100 AMI patients treated in our hospital were selected,and equally divided into clopidogrel group and combined treatment group(received clopidogrel combined aspirin).Both groups received routine treatment for 4 weeks.Total effective rate,platelet aggregation rate(PAR),coronary recanalization time,prothrombin time(PT),left ventricular ejection fraction(LVEF)and incidence rate of cardiovascular events during hospitalization were compared between two groups.Results:Total effective rate of combined treatment group was significantly higher than that of clopidogrel group(96.00% vs.80.00%,P=0.014).Compared with clopidogrel group after treatment,there were significant reductions in PAR [(47.63±7.83)% vs.(38.45±8.55)%],incidence rate of cardiovascular events(24.00%vs.4.00%)and coronary recanalization time[(45.44±4.42)vs.(41.93±5.85)],P and significant rise in LVEF[(48.56±5.79)% vs.(55.51±6.44)%]in combined treatment group,P<0.01 all.Conclusion:The clinical effect of clopidogrel combined with aspirin in the treatment of acute myocardial infarction is significant.
Objective:To comprehensively analyze therapeutic effect of clopidogrel combined aspirin on acute myocardial infarction(AMI).Methods:A total of 100 AMI patients treated in our hospital were selected,and equally divided into clopidogrel group and combined treatment group(received clopidogrel combined aspirin).Both groups received routine treatment for 4 weeks.Total effective rate,platelet aggregation rate(PAR),coronary recanalization time,prothrombin time(PT),left ventricular ejection fraction(LVEF)and incidence rate of cardiovascular events during hospitalization were compared between two groups.Results:Total effective rate of combined treatment group was significantly higher than that of clopidogrel group(96.00% vs.80.00%,P=0.014).Compared with clopidogrel group after treatment,there were significant reductions in PAR [(47.63±7.83)% vs.(38.45±8.55)%],incidence rate of cardiovascular events(24.00%vs.4.00%)and coronary recanalization time[(45.44±4.42)vs.(41.93±5.85)],P and significant rise in LVEF[(48.56±5.79)% vs.(55.51±6.44)%]in combined treatment group,P<0.01 all.Conclusion:The clinical effect of clopidogrel combined with aspirin in the treatment of acute myocardial infarction is significant.
引文
[1]Hasanzadeh M,Shadjou N,Soleymani J,et al.Optical immunosensing of effective cardiac biomarkers on acute myocardial infarction(Review)[J].TrAC:Trends in Analytical Chemistry,2013,51(4):158-168.
[2]Kong T,Su R,Zhang B,et al.CMOS-compatible,label-free silicon-nanowire biosensors to detect cardiac troponin I for acute myocardial infarction diagnosis[J].Biosens Bioelectron,2012,34(4):267-272.
[3]Paradela-Dobarro B,Raposeiras-Roubín S,Rodio-Janeiro BK,et al.Statins modulate feedback regulation mechanisms between advanced glycation end-products and C-reactive protein:Evidence in patients with acute myocardial infarction[J].Eur JPharm Sci,2013,49(4):512-518.
[4]高海,严研,李南,等.不同质子泵抑制剂对急性心肌梗死患者直接经皮冠状动脉介入治疗的影响[J].中华老年心脑血管病杂志,2012,14(7):707-710.
[5]赵亚男,王晨,蔚有权,等.氯吡格雷联合阿司匹林治疗急性心肌梗死的临床研究[J].中国临床药理学杂志,2015,11(8):595-598.
[6]牛少辉,张丽华,简立国,等.氯吡格雷联合阿司匹林治疗急性心肌梗死的疗效观察[J].中国临床医学,2014,21(2):151-153.
[7]李红娟,李文娟,田洪森,等.氯吡格雷联合阿司匹林治疗急性心肌梗死的效果观察[J].国际医药卫生导报,2015,21(5):679-681.
[8]Hyojeong Han,Hong Seog Seo,Byung Hwa Jung,et al.Substance P and Neuropeptide Y as Potential Biomarkers for Diagnosis of Acute Myocardial Infarction in Korean Patients[J].Bull Korean Chem Soc,2014,35(1):158-164.
[9]Trieb T,Mayr A,Klug G,et al.Patterns of myocardial perfusion in the acute and chronic stage after myocardial infarction:A cardiac magnetic resonance study[J].Eur J Radiol,2012,81(4):767-772.
[10]Almamun M,Rumana N,Kita Y,et al.Combining the effects of conventional risk factors and environmental triggering factors while studying seasonality in acute myocardial infarction[J].Environl Pollut,2014,189:252-253.
[11]陈洪云,刘玲,吴猛,等.参附注射液联合阿司匹林与氯吡格雷和低分子肝素治疗急性心肌梗死的急救体会[J].中国中西医结合急救杂志,2016,23(4):431-432.
[12]黄攀登,吴远慧,谷伟,等.麝香保心丸联合西药治疗老年急性心肌梗死的临床疗效[J].中国循证心血管医学杂志,2016,8(9):1096-1099.
[13]赵群.探讨急性心肌梗死患者应用氯吡格雷、阿司匹林联合治疗效果与泮托拉唑短期应用的关系[J].当代医学,2016,22(25):149-150.
[14]黄思玉,张俊川,李广红,等.氯吡格雷联合阿司匹林治疗老年ST段抬高型急性心肌梗死的疗效及安全性分析[J].中国临床保健杂志,2013,19(6):623-625.
[15]许圆圆,支继新,孙超宇,等.替罗非班联合重组人脑利钠肽治疗急性心肌梗死伴心力衰竭患者的疗效分析[J].中国急救医学,2013,33(4):330-332.
[16]王小东,庄少伟,张旭敏等.替格瑞洛对老年急性心肌梗死患者血小板功能及临床预后的影响[J].国际心血管病杂志,2016,43(3):183-186.
[17]吴荣恒.不稳定型心绞痛应用氯吡格雷联合阿司匹林治疗的效果观察[J].中国药物与临床,2013,13(11):1473-1474.
[18]贾珠银,杨建敏.替格瑞洛联合阿司匹林治疗急性冠状动脉综合征的临床研究[J].中国临床药理学杂志,2016,32(14):1254-1256,1282.
[19]罗晓鸣,邹剑杰,张伯超,等.瑞舒伐他汀联合硫酸氢氯吡格雷对冠心病患者的临床疗效[J].心血管康复医学杂志,2017,26(4):441-444.
[2]Kong T,Su R,Zhang B,et al.CMOS-compatible,label-free silicon-nanowire biosensors to detect cardiac troponin I for acute myocardial infarction diagnosis[J].Biosens Bioelectron,2012,34(4):267-272.
[3]Paradela-Dobarro B,Raposeiras-Roubín S,Rodio-Janeiro BK,et al.Statins modulate feedback regulation mechanisms between advanced glycation end-products and C-reactive protein:Evidence in patients with acute myocardial infarction[J].Eur JPharm Sci,2013,49(4):512-518.
[4]高海,严研,李南,等.不同质子泵抑制剂对急性心肌梗死患者直接经皮冠状动脉介入治疗的影响[J].中华老年心脑血管病杂志,2012,14(7):707-710.
[5]赵亚男,王晨,蔚有权,等.氯吡格雷联合阿司匹林治疗急性心肌梗死的临床研究[J].中国临床药理学杂志,2015,11(8):595-598.
[6]牛少辉,张丽华,简立国,等.氯吡格雷联合阿司匹林治疗急性心肌梗死的疗效观察[J].中国临床医学,2014,21(2):151-153.
[7]李红娟,李文娟,田洪森,等.氯吡格雷联合阿司匹林治疗急性心肌梗死的效果观察[J].国际医药卫生导报,2015,21(5):679-681.
[8]Hyojeong Han,Hong Seog Seo,Byung Hwa Jung,et al.Substance P and Neuropeptide Y as Potential Biomarkers for Diagnosis of Acute Myocardial Infarction in Korean Patients[J].Bull Korean Chem Soc,2014,35(1):158-164.
[9]Trieb T,Mayr A,Klug G,et al.Patterns of myocardial perfusion in the acute and chronic stage after myocardial infarction:A cardiac magnetic resonance study[J].Eur J Radiol,2012,81(4):767-772.
[10]Almamun M,Rumana N,Kita Y,et al.Combining the effects of conventional risk factors and environmental triggering factors while studying seasonality in acute myocardial infarction[J].Environl Pollut,2014,189:252-253.
[11]陈洪云,刘玲,吴猛,等.参附注射液联合阿司匹林与氯吡格雷和低分子肝素治疗急性心肌梗死的急救体会[J].中国中西医结合急救杂志,2016,23(4):431-432.
[12]黄攀登,吴远慧,谷伟,等.麝香保心丸联合西药治疗老年急性心肌梗死的临床疗效[J].中国循证心血管医学杂志,2016,8(9):1096-1099.
[13]赵群.探讨急性心肌梗死患者应用氯吡格雷、阿司匹林联合治疗效果与泮托拉唑短期应用的关系[J].当代医学,2016,22(25):149-150.
[14]黄思玉,张俊川,李广红,等.氯吡格雷联合阿司匹林治疗老年ST段抬高型急性心肌梗死的疗效及安全性分析[J].中国临床保健杂志,2013,19(6):623-625.
[15]许圆圆,支继新,孙超宇,等.替罗非班联合重组人脑利钠肽治疗急性心肌梗死伴心力衰竭患者的疗效分析[J].中国急救医学,2013,33(4):330-332.
[16]王小东,庄少伟,张旭敏等.替格瑞洛对老年急性心肌梗死患者血小板功能及临床预后的影响[J].国际心血管病杂志,2016,43(3):183-186.
[17]吴荣恒.不稳定型心绞痛应用氯吡格雷联合阿司匹林治疗的效果观察[J].中国药物与临床,2013,13(11):1473-1474.
[18]贾珠银,杨建敏.替格瑞洛联合阿司匹林治疗急性冠状动脉综合征的临床研究[J].中国临床药理学杂志,2016,32(14):1254-1256,1282.
[19]罗晓鸣,邹剑杰,张伯超,等.瑞舒伐他汀联合硫酸氢氯吡格雷对冠心病患者的临床疗效[J].心血管康复医学杂志,2017,26(4):441-444.